CD6
Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS. Detected on thymocytes (PubMed:15294938). Detected on peripheral blood T-cells (PubMed:15048703, PubMed:16352806). Detected on natural killer (NK) cells (PubMed:16352806). Soluble CD6 is detected in blood serum (at protein level) (PubMed:17601777). Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes (PubMed:9013954). Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell surface; Membrane protein, integral |
Chromosomal Location of mouse Ortholog: 19 A|19 7.16 cM |
Cellular Component:
cell surface; immunological synapse; membrane; plasma membrane; T cell receptor complex
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Molecular Function:
identical protein binding; lipopolysaccharide binding; lipoteichoic acid binding; protein binding; protein kinase binding; scavenger receptor activity
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Biological Process:
acute inflammatory response to antigenic stimulus; cell adhesion; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; immunological synapse formation; lipopolysaccharide-mediated signaling pathway; positive regulation of cytokine production involved in inflammatory response; positive regulation of protein phosphorylation; positive regulation of T cell proliferation; response to lipopolysaccharide
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Reference #:
Q61003
(UniProtKB)
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Alt. Names/Synonyms: Cd6; CD6 antigen; T-cell differentiation antigen CD6
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Gene Symbols: Cd6
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Molecular weight:
72,255 Da
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Basal Isoelectric point:
5.07
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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