CD6 Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS. Detected on thymocytes (PubMed:15294938). Detected on peripheral blood T-cells (PubMed:15048703, PubMed:16352806). Detected on natural killer (NK) cells (PubMed:16352806). Soluble CD6 is detected in blood serum (at protein level) (PubMed:17601777). Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes (PubMed:9013954). Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of mouse Ortholog: 19 A|19 7.16 cM
Cellular Component:  external side of plasma membrane; immunological synapse; membrane; plasma membrane; T cell receptor complex
Molecular Function:  identical protein binding; lipopolysaccharide binding; lipoteichoic acid binding; protein binding; protein kinase binding; scavenger receptor activity
Biological Process:  acute inflammatory response to antigenic stimulus; cell adhesion; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; immunological synapse formation; lipopolysaccharide-mediated signaling pathway; positive regulation of cytokine production involved in inflammatory response; positive regulation of protein phosphorylation; positive regulation of T cell proliferation; response to lipopolysaccharide
Reference #:  Q61003 (UniProtKB)
Alt. Names/Synonyms: Cd6; CD6 antigen; T-cell differentiation antigen CD6
Gene Symbols: Cd6
Molecular weight: 72,255 Da
Basal Isoelectric point: 5.07  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene