RELB a subunit of NF-kappa-B transcription complex (NFkB), which plays a crucial role in biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFkB consists of homo- or heterodimeric complexes formed from the five NFkB proteins in mammals: RelA, RelB, c-REL, NFkB1, and NFkB2. They form a variety of homodimers and heterodimers, each binding at kappa-B sites in the DNA, regulating distinct sets of genes. Different dimer combinations act as transcriptional activators or repressors. Stimulates promoter activity in the presence of isoform 3 of NFKB2. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Is required for both T and B lymphocyte maturation and function. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of human Ortholog: 19q13.32
Cellular Component:  centrosome; chromatin; cytosol; NF-kappaB complex; nucleoplasm; nucleus; protein-containing complex; synapse; transcription repressor complex
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Process:  antigen processing and presentation; cellular response to osmotic stress; cellular response to stress; circadian regulation of gene expression; I-kappaB kinase/NF-kappaB signaling; inflammatory response; innate immune response; lymphocyte differentiation; myeloid dendritic cell differentiation; negative regulation of DNA-templated transcription; negative regulation of interferon-beta production; NIK/NF-kappaB signaling; positive regulation of transcription by RNA polymerase II; response to cytokine; T-helper 1 cell differentiation
Disease: Immunodeficiency 53
Reference #:  Q01201 (UniProtKB)
Alt. Names/Synonyms: I-Rel; IMD53; IREL; REL-B; RELB; RELB proto-oncogene, NF-kB subunit; Transcription factor RelB; v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3); v-rel reticuloendotheliosis viral oncogene homolog B; v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
Gene Symbols: RELB
Molecular weight: 62,134 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein