MKK6 iso2 a dual-specificity protein kinase of the STE7 family. Activates p38 MAP kinase by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by cytokines and environmental stress in vivo. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family

Chromosomal Location of Human Ortholog: 17q24.3

Cellular Component: cytoskeleton; cytosol; nucleoplasm; nucleus

Molecular Function: ATP binding; MAP kinase kinase activity; protein binding; protein kinase binding; protein serine/threonine kinase activity; protein tyrosine kinase activity

Biological Process: activation of MAPK activity; apoptotic process; cardiac muscle contraction; cell cycle arrest; cellular response to sorbitol; DNA damage induced protein phosphorylation; MAPK cascade; negative regulation of cold-induced thermogenesis; nucleotide-binding oligomerization domain containing signaling pathway; ovulation cycle process; peptidyl-tyrosine phosphorylation; positive regulation of apoptotic process; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of prostaglandin secretion; response to drug; response to ischemia; signal transduction

Reference #: P52564-2 (UniProtKB)

Alt. Names/Synonyms: Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAP2K6; MAPK/ERK kinase 6; MAPKK 6; MAPKK6; MEK 6; MEK6; mitogen-activated protein kinase kinase 6; MKK6; MP2K6; PRKMK6; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); SAPKK3

Gene Symbols: MAP2K6

Molecular weight: 31,339 Da

Basal Isoelectric point: 6.61 Predict pI for various phosphorylation states

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MKK6 iso2

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