MKK6 iso2 a dual-specificity protein kinase of the STE7 family. Activates p38 MAP kinase by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by cytokines and environmental stress in vivo. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Chromosomal Location of Human Ortholog: 17q24.3
Cellular Component:  cytoskeleton; cytosol; nucleoplasm; nucleus
Molecular Function:  ATP binding; MAP kinase kinase activity; protein binding; protein kinase binding; protein serine/threonine kinase activity; protein tyrosine kinase activity
Biological Process:  activation of MAPK activity; apoptotic process; cardiac muscle contraction; cell cycle arrest; cellular response to sorbitol; DNA damage induced protein phosphorylation; MAPK cascade; negative regulation of cold-induced thermogenesis; nucleotide-binding oligomerization domain containing signaling pathway; ovulation cycle process; peptidyl-tyrosine phosphorylation; positive regulation of apoptotic process; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of prostaglandin secretion; response to drug; response to ischemia; signal transduction
Reference #:  P52564-2 (UniProtKB)
Alt. Names/Synonyms: Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAP2K6; MAPK/ERK kinase 6; MAPKK 6; MAPKK6; MEK 6; MEK6; mitogen-activated protein kinase kinase 6; MKK6; MP2K6; PRKMK6; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); SAPKK3
Gene Symbols: MAP2K6
Molecular weight: 31,339 Da
Basal Isoelectric point: 6.61  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Regulation of P38 MAPKs  |  TGF-ß Signaling  |  Toll-Like Receptor Signaling
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MKK6 iso2

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein