SGK223 Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth. Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism. Acts as a critical coactivator of Notch signaling. Belongs to the protein kinase superfamily. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Motility/polarity/chemotaxis; NKF3 family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 8p23.1
Cellular Component:  cytoplasm; focal adhesion; nucleus
Molecular Function:  identical protein binding; protein binding
Biological Process:  cell migration; negative regulation of neuron projection development; positive regulation of Rho protein signal transduction; regulation of cell motility; regulation of cell shape; regulation of Notch signaling pathway
Reference #:  Q86YV5 (UniProtKB)
Alt. Names/Synonyms: DKFZp761P0423; homolog of rat pragma of Rnd2; Inactive tyrosine-protein kinase PRAG1; NACK; PEAK family member 2; PEAK1 related, kinase-activating pseudokinase 1; PEAK1-related kinase-activating pseudokinase 1; PEAK2; PRAG1; PRAGMIN; Pragmin, RND2 effector protein; SG223; SGK223; Sugen kinase 223; Tyrosine-protein kinase PRAG1; Tyrosine-protein kinase SgK223
Gene Symbols: PRAG1
Molecular weight: 149,624 Da
Basal Isoelectric point: 6.83  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB