calsenilin Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception. Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation. Belongs to the recoverin family. Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Transcription factor
Chromosomal Location of Human Ortholog: 2q11.1
Cellular Component:  axon terminus; cytosol; dendrite; endoplasmic reticulum; Golgi apparatus; nucleus; plasma membrane; protein-DNA complex; voltage-gated potassium channel complex
Molecular Function:  calcium ion binding; DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; ion channel binding; potassium channel activity; potassium channel regulator activity; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription corepressor activity; voltage-gated ion channel activity
Biological Process:  apoptotic process; cardiac conduction; intracellular protein transport; negative regulation of transcription by RNA polymerase II; potassium ion transmembrane transport; protein localization to plasma membrane; regulation of potassium ion transmembrane transport; regulation of transcription by RNA polymerase II; signal transduction
Reference #:  Q9Y2W7 (UniProtKB)
Alt. Names/Synonyms: A-type potassium channel modulatory protein 3; Calsenilin; calsenilin, presenilin-binding protein, EF hand transcription factor; CSEN; DRE-antagonist modulator; DREAM; KCHIP3; KCNIP3; Kv channel interacting protein 3; Kv channel interacting protein 3, calsenilin; Kv channel-interacting protein 3; MGC18289; potassium channel interacting protein 3
Gene Symbols: KCNIP3
Molecular weight: 29,231 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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