MARK2 Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. High levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney. 16 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMKL family; EC 2.7.11.1; EC 2.7.11.26; Kinase, protein; MARK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 19 A|19 5.32 cM
Cellular Component:  actin filament; basal cortex; cell projection; cytoplasm; cytoskeleton; dendrite; lateral plasma membrane; membrane; microtubule bundle; nucleoplasm; nucleus; plasma membrane
Molecular Function:  ATP binding; kinase activity; lipid binding; magnesium ion binding; metal ion binding; nucleotide binding; protein kinase activity; protein N-terminus binding; protein serine/threonine kinase activity; tau protein binding; tau-protein kinase activity; transferase activity
Biological Process:  axon development; cell differentiation; establishment of cell polarity; establishment or maintenance of cell polarity regulating cell shape; establishment or maintenance of epithelial cell apical/basal polarity; intracellular signal transduction; microtubule cytoskeleton organization; multicellular organism development; neuron migration; peptidyl-serine phosphorylation; phosphorylation; positive regulation of neuron projection development; protein autophosphorylation; protein phosphorylation; regulation of axonogenesis; regulation of cytoskeleton organization; regulation of microtubule binding; regulation of microtubule cytoskeleton organization; Wnt signaling pathway
Reference #:  Q05512 (UniProtKB)
Alt. Names/Synonyms: AU024026; ELKL motif kinase 1; Emk; EMK-1; KIAA4207; MAP/microtubule affinity regulating kinase 2; MAP/microtubule affinity-regulating kinase 2; Mark2; mKIAA4207; mPar-1b; Par-1; Par-1b; PAR1 homolog; PAR1 homolog b; Serine/threonine-protein kinase MARK2
Gene Symbols: Mark2
Molecular weight: 86,306 Da
Basal Isoelectric point: 9.7  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MARK2

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Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene