DCAMKL1 a serine-threonine kinase of the CAMK family. May be involved in a calcium-signaling pathway controling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. Genetic and physical interactions with Doublecortin, which causes lissencephaly. A putative marker of quiescent stem cells. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: CAMK group; DCAMKL family; EC 2.7.11.1; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 3|3 C
Cellular Component:  postsynaptic density
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein kinase activity; transferase activity
Biological Process:  axon extension; axonogenesis; brain development; cell differentiation; central nervous system projection neuron axonogenesis; dendrite morphogenesis; forebrain development; multicellular organism development; negative regulation of protein localization to nucleus; nervous system development; neuron migration; neuron projection morphogenesis; peptidyl-serine phosphorylation; phosphorylation; protein amino acid phosphorylation
Reference #:  Q9JLM8 (UniProtKB)
Alt. Names/Synonyms: 1700113D08Rik; 2810480F11Rik; AI836758; Click-I; CLICK-I beta; Cpg16; Dcamkl1; Dcl; Dclk; Dclk1; doublecortin and calcium/calmodulin-dependent protein kinase-like 1; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1; mKIAA0369; Serine/threonine-protein kinase DCLK1
Gene Symbols: Dclk1
Molecular weight: 84,153 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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DCAMKL1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA