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ACTN1
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Belongs to the alpha-actinin family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of rat Ortholog: 6q24 |
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Cellular Component:
actin filament; bicellular tight junction; brush border; cell junction; cell leading edge; cell projection; cell-cell junction; cellular anatomical entity; cortical actin cytoskeleton; cytoplasm; cytoskeleton; cytosol; dendritic spine; dense body; fascia adherens; focal adhesion; glutamatergic synapse; inner dense plaque of desmosome; lamellipodium; lateral plasma membrane; outer dense plaque of desmosome; plasma membrane; ruffle; sarcolemma; sarcomere; smooth muscle dense body; stress fiber; terminal web; Z disc; zonula adherens
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Molecular Function:
actin binding; actin filament binding; alpha-actinin binding; calcium ion binding; cytoskeletal regulatory protein binding; double-stranded RNA binding; integrin binding; nuclear receptor coactivator activity; protein binding; protein domain specific binding; protein homodimerization activity; structural constituent of postsynapse; transmembrane transporter binding; vinculin binding
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Biological Process:
actin cytoskeleton organization; actin filament bundle assembly; actin filament network formation; actin filament organization; focal adhesion assembly; muscle cell development; platelet activation; platelet aggregation; platelet formation; platelet morphogenesis; positive regulation of DNA-templated transcription; postsynapse organization; sarcomere organization; skeletal muscle fiber development
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Reference #:
Q9Z1P2
(UniProtKB)
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Alt. Names/Synonyms: actinin, alpha 1; Actn1; Alpha-actinin cytoskeletal isoform; Alpha-actinin-1; non-muscle alpha-actinin 1; Non-muscle alpha-actinin-1
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Gene Symbols: Actn1
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Molecular weight:
102,960 Da
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Basal Isoelectric point:
5.23
Predict pI for various phosphorylation states
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CST Pathways:
T Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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