ACTN1 F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Belongs to the alpha-actinin family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of rat Ortholog: 6q24
Cellular Component:  actin filament; bicellular tight junction; brush border; cell junction; cell leading edge; cell projection; cell-cell junction; cytoplasm; cytosol; dendritic spine; dense body; fascia adherens; focal adhesion; glutamatergic synapse; inner dense plaque of desmosome; lamellipodium; lateral plasma membrane; nucleus; outer dense plaque of desmosome; plasma membrane; ruffle; sarcolemma; sarcomere; smooth muscle dense body; stress fiber; terminal web; Z disc; zonula adherens
Molecular Function:  actin filament binding; alpha-actinin binding; calcium ion binding; double-stranded RNA binding; integrin binding; ion channel binding; nuclear receptor transcription coactivator activity; protein binding; protein domain specific binding; protein homodimerization activity; structural constituent of postsynapse; vinculin binding
Biological Process:  actin crosslink formation; actin filament bundle assembly; actin filament network formation; actin filament organization; focal adhesion assembly; negative regulation of cellular component movement; platelet formation; platelet morphogenesis; positive regulation of nucleic acid-templated transcription; postsynapse organization; sarcomere organization; skeletal muscle fiber development
Reference #:  Q9Z1P2 (UniProtKB)
Alt. Names/Synonyms: actinin, alpha 1; Actn1; Alpha-actinin cytoskeletal isoform; Alpha-actinin-1; non-muscle alpha-actinin 1; Non-muscle alpha-actinin-1
Gene Symbols: Actn1
Molecular weight: 102,960 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene