ACTN1 F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Belongs to the alpha-actinin family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 14q24.1|14q22-q24
Cellular Component:  actin filament; brush border; cell junction; cell projection; cell-cell junction; cortical actin cytoskeleton; cytoplasm; cytosol; extracellular region; fascia adherens; focal adhesion; glutamatergic synapse; plasma membrane; platelet alpha granule lumen; pseudopodium; ruffle; stress fiber; Z disc
Molecular Function:  actin filament binding; calcium ion binding; double-stranded RNA binding; integrin binding; nuclear receptor coactivator activity; protein binding; protein homodimerization activity; structural constituent of postsynapse; transmembrane transporter binding; vinculin binding
Biological Process:  actin cytoskeleton organization; actin filament bundle assembly; actin filament network formation; actin filament organization; focal adhesion assembly; muscle cell development; platelet activation; platelet aggregation; platelet formation; platelet morphogenesis; positive regulation of DNA-templated transcription; postsynapse organization; regulation of apoptotic process
Disease: Bleeding Disorder, Platelet-type, 15
Reference #:  P12814 (UniProtKB)
Alt. Names/Synonyms: actinin 1 smooth muscle; actinin alpha 1; actinin, alpha 1; ACTN1; alpha-actinin; alpha-actinin 1; Alpha-actinin cytoskeletal isoform; Alpha-actinin-1; BDPLT15; epididymis secretory sperm binding protein; F-actin cross-linking protein; FLJ40884; FLJ54432; Non-muscle alpha-actinin-1
Gene Symbols: ACTN1
Molecular weight: 103,058 Da
Basal Isoelectric point: 5.25  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein