caveolin-2 May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression. Belongs to the caveolin family. Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts. 3 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q31.2
Cellular Component:  acrosomal membrane; caveola; cytoplasmic vesicle; extrinsic component of cytoplasmic side of plasma membrane; Golgi apparatus; Golgi membrane; integral component of plasma membrane; membrane raft; nucleus; perinuclear region of cytoplasm; plasma membrane; protein-containing complex; transport vesicle
Molecular Function:  protein binding; protein binding, bridging; protein heterodimerization activity; protein homodimerization activity; scaffold protein binding
Biological Process:  caveola assembly; endoplasmic reticulum organization; insulin receptor signaling pathway; mitochondrion organization; negative regulation of endothelial cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation by host of viral process; positive regulation by host of viral release from host cell; positive regulation of dopamine receptor signaling pathway; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of MAPK cascade; protein complex oligomerization; receptor-mediated endocytosis of virus by host cell; regulation of mitotic nuclear division; skeletal muscle fiber development; vesicle docking; vesicle fusion; vesicle organization
Reference #:  P51636 (UniProtKB)
Alt. Names/Synonyms: CAV; CAV2; caveolae protein, 20-kD; caveolin 2; caveolin 2 isoform a and b; Caveolin-2; MGC12294
Gene Symbols: CAV2
Molecular weight: 18,291 Da
Basal Isoelectric point: 5.06  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ErbB/HER Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein