caveolin-2 a scaffolding protein. A component of caveolae, small invaginations of the plasma membrane found in most cell types. Involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-2 may function as an accessory protein in conjunction with caveolin-1. Two splice-variant isoforms have been observed. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q31.2
Cellular Component:  acrosomal membrane; caveola; cytoplasmic vesicle; extrinsic component of cytoplasmic side of plasma membrane; Golgi apparatus; Golgi membrane; integral component of plasma membrane; membrane raft; nucleus; perinuclear region of cytoplasm; plasma membrane; protein-containing complex; transport vesicle
Molecular Function:  protein binding; protein binding, bridging; protein heterodimerization activity; protein homodimerization activity; scaffold protein binding
Biological Process:  caveola assembly; endoplasmic reticulum organization; insulin receptor signaling pathway; mitochondrion organization; negative regulation of endothelial cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation by host of viral process; positive regulation by host of viral release from host cell; positive regulation of dopamine receptor signaling pathway; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of MAPK cascade; protein complex oligomerization; receptor-mediated endocytosis of virus by host cell; regulation of mitotic nuclear division; skeletal muscle fiber development; vesicle docking; vesicle fusion; vesicle organization
Reference #:  P51636 (UniProtKB)
Alt. Names/Synonyms: CAV; CAV2; caveolae protein, 20-kD; caveolin 2; caveolin 2 isoform a and b; Caveolin-2; MGC12294
Gene Symbols: CAV2
Molecular weight: 18,291 Da
Basal Isoelectric point: 5.06  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ErbB/HER Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein