ITGB4 iso2 Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. Belongs to the integrin beta chain family. Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of human Ortholog: 17q25.1
Cellular Component:  basal plasma membrane; basement membrane; cell junction; cell leading edge; cell surface; focal adhesion; hemidesmosome; integrin complex; nuclear membrane; nucleolus; plasma membrane; receptor complex
Molecular Function:  G protein-coupled receptor binding; insulin-like growth factor I binding; integrin binding; neuregulin binding; protein binding
Biological Process:  autophagy; cell adhesion; cell adhesion mediated by integrin; cell migration; cell motility; cell-matrix adhesion; filopodium assembly; hemidesmosome assembly; integrin-mediated signaling pathway; mesodermal cell differentiation; nail development; peripheral nervous system myelin formation; response to wounding; skin morphogenesis; trophoblast cell migration
Disease: Epidermolysis Bullosa Junctionalis With Pyloric Atresia; Epidermolysis Bullosa, Junctional 5a, Intermediate
Reference #:  P16144-2 (UniProtKB)
Alt. Names/Synonyms: CD104; CD104 antigen; GP150; Integrin beta-4; integrin beta-4 subunit; integrin subunit beta 4; integrin, beta 4; ITB4; ITGB4; ITGB4 iso2
Gene Symbols: ITGB4
Molecular weight: 195,013 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
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ITGB4 iso2

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Protein Atlas  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein