Hrs Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10q32.3
Cellular Component:  cytoplasm; cytosol; early endosome; early endosome membrane; endosome; ESCRT-0 complex; intracellular membrane-bounded organelle; lysosome; membrane; multivesicular body membrane; secretory granule
Molecular Function:  identical protein binding; metal ion binding; protein binding; protein domain specific binding; ubiquitin-dependent protein binding; ubiquitin-like protein ligase binding
Biological Process:  endosome to lysosome transport; intracellular protein transport; membrane invagination; negative regulation of angiogenesis; negative regulation of JAK-STAT cascade; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of exosomal secretion; positive regulation of gene expression; protein localization to membrane; protein targeting to lysosome; regulation of MAP kinase activity
Reference #:  Q9JJ50 (UniProtKB)
Alt. Names/Synonyms: Hepatocyte growth factor-regulated tyrosine kinase substrate; HGF-regulated tyrosine kinase substrate; Hgs; Hrs; Hrs2; SNAP-25-interacting protein Hrs-2
Gene Symbols: Hgs
Molecular weight: 86,246 Da
Basal Isoelectric point: 5.91  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene