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MAZ
May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; RNA-binding; Transcription factor |
| Chromosomal Location of mouse Ortholog: 7|7 F3 |
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Cellular Component:
cytoplasm; nucleus
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Molecular Function:
chromatin binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding
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Biological Process:
negative regulation of apoptotic signaling pathway; negative regulation of transcription by RNA polymerase II; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase B signaling; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; termination of RNA polymerase II transcription; transcription initiation at RNA polymerase II promoter
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Reference #:
P56671
(UniProtKB)
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Alt. Names/Synonyms: Maz; MAZI; Myc-associated zinc finger protein; MYC-associated zinc finger protein (purine-binding transcription factor); Pur; Pur-1; PUR1; Purine-binding transcription factor; SAF; SAF-1; SAF-2
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Gene Symbols: Maz
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Molecular weight:
48,770 Da
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Basal Isoelectric point:
9.21
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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