MAZ May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; RNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component:  nucleus
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding
Biological Process:  negative regulation of apoptotic signaling pathway; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein kinase B signaling; positive regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; termination of RNA polymerase II transcription; transcription initiation from RNA polymerase II promoter
Reference #:  P56270 (UniProtKB)
Alt. Names/Synonyms: MAZ; MAZI; Myc-associated zinc finger protein; MYC-associated zinc finger protein (purine-binding transcription factor); Pur-1; PUR1; Purine-binding transcription factor; SAF-1; SAF-2; SAF-3; serum amyloid A activating factor 1; serum amyloid A activating factor 2; ZF87; ZIF87; zinc-finger protein, 87 kilodaltons; ZNF801
Gene Symbols: MAZ
Molecular weight: 48,608 Da
Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states
Select Structure to View Below

MAZ

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene