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BACE
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Cleaves APP with much more catalytic efficiency than for the wild-type. Belongs to the peptidase A1 family. Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.23.46; Membrane protein, integral; Protease |
| Chromosomal Location of Human Ortholog: 9|9 A5.2 |
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Cellular Component:
axon; cell surface; cytoplasmic vesicle; dendrite; early endosome; endoplasmic reticulum; endosome; Golgi apparatus; hippocampal mossy fiber to CA3 synapse; integral component of membrane; integral component of plasma membrane; late endosome; lysosome; membrane; multivesicular body; neuronal cell body; plasma membrane; presynapse; recycling endosome; synaptic vesicle; trans-Golgi network
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Molecular Function:
amyloid-beta binding; aspartic-type endopeptidase activity; endopeptidase activity; enzyme binding; hydrolase activity; peptidase activity; protein binding
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Biological Process:
amyloid-beta metabolic process; detection of mechanical stimulus involved in sensory perception of pain; membrane protein ectodomain proteolysis; memory; modulation of chemical synaptic transmission; positive regulation of neuron apoptotic process; prepulse inhibition; protein catabolic process; proteolysis; regulation of synaptic plasticity; regulation of synaptic vesicle exocytosis
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Reference #:
P56818
(UniProtKB)
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Alt. Names/Synonyms: APP beta-secretase; Asp 2; ASP2; Aspartyl protease 2; Bace; Bace1; Beta-secretase 1; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; C76936; Memapsin-2; Membrane-associated aspartic protease 2
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Gene Symbols: Bace1
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Molecular weight:
55,748 Da
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Basal Isoelectric point:
5.37
Predict pI for various phosphorylation states
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CST Pathways:
Alzheimer's Disease
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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