BACE Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Cleaves APP with much more catalytic efficiency than for the wild-type. Belongs to the peptidase A1 family. Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.23.46; Membrane protein, integral; Protease
Chromosomal Location of human Ortholog: 11q23.3
Cellular Component:  axon; cell surface; cytoplasmic vesicle membrane; dendrite; early endosome; endoplasmic reticulum lumen; endosome; endosome membrane; Golgi apparatus; Golgi-associated vesicle lumen; hippocampal mossy fiber to CA3 synapse; integral component of membrane; integral component of plasma membrane; late endosome; lysosome; membrane raft; multivesicular body; neuronal cell body; plasma membrane; recycling endosome; synaptic vesicle; trans-Golgi network
Molecular Function:  amyloid-beta binding; aspartic-type endopeptidase activity; beta-aspartyl-peptidase activity; endopeptidase activity; enzyme binding; peptidase activity; protein binding
Biological Process:  amyloid-beta metabolic process; cellular protein metabolic process; cellular response to amyloid-beta; cellular response to copper ion; cellular response to manganese ion; detection of mechanical stimulus involved in sensory perception of pain; membrane protein ectodomain proteolysis; positive regulation of neuron apoptotic process; prepulse inhibition; proteolysis; regulation of synaptic vesicle exocytosis; response to lead ion; response to radiation
Reference #:  P56817 (UniProtKB)
Alt. Names/Synonyms: APP beta-secretase; Asp 2; ASP2; Aspartyl protease 2; BACE; BACE1; Beta-secretase 1; beta-secretase 1 precursor variant 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; beta-site APP-cleaving enzyme; beta-site APP-cleaving enzyme 1; FLJ90568; HSPC104; KIAA1149; Memapsin-2; Membrane-associated aspartic protease 2; transmembrane aspartic proteinase Asp2
Gene Symbols: BACE1
Molecular weight: 55,764 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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BACE

Protein Structure Not Found.