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STMN2
Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone. Belongs to the stathmin family. Neuron specific. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal |
| Chromosomal Location of rat Ortholog: 2q23 |
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Cellular Component:
cytoplasm; endosome; Golgi apparatus; growth cone; lamellipodium; membrane; neuron projection; neuronal cell body; perinuclear region of cytoplasm; vesicle
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Molecular Function:
calcium-dependent protein binding; protein binding; tubulin binding
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Biological Process:
cellular response to nerve growth factor stimulus; microtubule depolymerization; negative regulation of microtubule depolymerization; negative regulation of microtubule polymerization; negative regulation of neuron projection development; neuron projection development; positive regulation of microtubule depolymerization; positive regulation of neuron projection development; regulation of microtubule polymerization or depolymerization
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Reference #:
P21818
(UniProtKB)
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Alt. Names/Synonyms: MGC105372; Protein SCG10; Scg10; Scgn10; Stathmin-2; stathmin-like 2; Stmn2; Superior cervical ganglion-10 protein; superiorcervical ganglia, neural specific 10
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Gene Symbols: Stmn2
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Molecular weight:
20,756 Da
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Basal Isoelectric point:
8.73
Predict pI for various phosphorylation states
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CST Pathways:
Microtubule Dynamics
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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