LRP1 a receptor involved in endocytosis, phagocytosis of apoptotic cells, and neural signaling. Modulates cellular events including APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling and neurotransmission. Involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Plays a fundamental role in cellular signaling pathways in the brain. Mediates neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. A type I membrane protein. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. Most abundant in liver, brain and lung. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 10|10 D3
Cellular Component:  apical part of cell; axonal growth cone; basolateral plasma membrane; clathrin-coated pit; clathrin-coated vesicle; cytoplasm; dendrite; early endosome; endosome; insulin-responsive compartment; integral component of membrane; integral component of plasma membrane; membrane; neuronal cell body; nucleus; perinuclear region of cytoplasm; plasma membrane; receptor complex
Molecular Function:  alpha-2 macroglobulin receptor activity; apolipoprotein binding; calcium ion binding; cargo receptor activity; clathrin heavy chain binding; coreceptor activity; metal ion binding; protease binding; protein binding; protein-containing complex binding
Biological Process:  amyloid-beta clearance; amyloid-beta clearance by cellular catabolic process; amyloid-beta clearance by transcytosis; aorta morphogenesis; apoptotic cell clearance; astrocyte activation involved in immune response; cardiac septum development; cell proliferation; cellular lipid catabolic process; cellular response to amyloid-beta; chemoattraction of axon; cholesterol metabolic process; coronary vasculature development; endocytosis; lysosomal transport; multicellular organism development; negative regulation of apoptotic process; negative regulation of cell death; negative regulation of cell-substrate adhesion; negative regulation of cytosolic calcium ion concentration; negative regulation of focal adhesion assembly; negative regulation of neuron apoptotic process; negative regulation of neuron projection development; negative regulation of platelet-derived growth factor receptor-beta signaling pathway; negative regulation of smooth muscle cell migration; negative regulation of Wnt signaling pathway; phagocytosis; positive regulation of axon extension; positive regulation of axon extension involved in regeneration; positive regulation of cell death; positive regulation of chemokine (C-C motif) ligand 2 secretion; positive regulation of cholesterol efflux; positive regulation of cholesterol import; positive regulation of collateral sprouting of injured axon; positive regulation of cytosolic calcium ion concentration; positive regulation of endocytosis; positive regulation of ERK1 and ERK2 cascade; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of lipid transport; positive regulation of lysosomal protein catabolic process; positive regulation of neuron projection development; positive regulation of phagocytosis; positive regulation of protein binding; positive regulation of protein localization to plasma membrane; positive regulation of protein transport; positive regulation of Schwann cell migration; positive regulation of vascular associated smooth muscle cell migration; protein kinase C-activating G protein-coupled receptor signaling pathway; receptor-mediated endocytosis; regulation of actin cytoskeleton organization; regulation of cholesterol transport; regulation of phospholipase A2 activity
Reference #:  Q91ZX7 (UniProtKB)
Alt. Names/Synonyms: A2MR; AI316852; alpha 2-macroglobulin receptor; Alpha-2-macroglobulin receptor; CD91; lipoprotein receptor-related protein; low density lipoprotein receptor-related protein 1; Low-density lipoprotein receptor-related protein 1 515 kDa subunit; Low-density lipoprotein receptor-related protein 1 85 kDa subunit; Low-density lipoprotein receptor-related protein 1 intracellular domain; Lrp; LRP-1; LRP-515; LRP-85; Lrp1; LRPICD; Prolow-density lipoprotein receptor-related protein 1
Gene Symbols: Lrp1
Molecular weight: 504,742 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene