LRP1 Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Acts as an alpha-2-macroglobulin receptor. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. Belongs to the LDLR family. Most abundant in liver, brain and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 10|10 D3
Cellular Component:  apical part of cell; axonal growth cone; basolateral plasma membrane; clathrin-coated pit; clathrin-coated vesicle; cytoplasm; dendrite; early endosome; endosome; insulin-responsive compartment; integral component of membrane; integral component of plasma membrane; membrane; neuronal cell body; nucleus; perinuclear region of cytoplasm; plasma membrane; receptor complex
Molecular Function:  alpha-2 macroglobulin receptor activity; apolipoprotein binding; calcium ion binding; cargo receptor activity; clathrin heavy chain binding; coreceptor activity; metal ion binding; protease binding; protein binding; protein-containing complex binding
Biological Process:  amyloid-beta clearance; amyloid-beta clearance by cellular catabolic process; amyloid-beta clearance by transcytosis; aorta morphogenesis; apoptotic cell clearance; astrocyte activation involved in immune response; cardiac septum development; cell proliferation; cellular lipid catabolic process; cellular response to amyloid-beta; chemoattraction of axon; cholesterol metabolic process; coronary vasculature development; endocytosis; lysosomal transport; multicellular organism development; negative regulation of apoptotic process; negative regulation of cell death; negative regulation of cell-substrate adhesion; negative regulation of cytosolic calcium ion concentration; negative regulation of focal adhesion assembly; negative regulation of neuron apoptotic process; negative regulation of neuron projection development; negative regulation of platelet-derived growth factor receptor-beta signaling pathway; negative regulation of smooth muscle cell migration; negative regulation of Wnt signaling pathway; phagocytosis; positive regulation of axon extension; positive regulation of axon extension involved in regeneration; positive regulation of cell death; positive regulation of chemokine (C-C motif) ligand 2 secretion; positive regulation of cholesterol efflux; positive regulation of cholesterol import; positive regulation of collateral sprouting of injured axon; positive regulation of cytosolic calcium ion concentration; positive regulation of endocytosis; positive regulation of ERK1 and ERK2 cascade; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of lipid transport; positive regulation of lysosomal protein catabolic process; positive regulation of neuron projection development; positive regulation of phagocytosis; positive regulation of protein binding; positive regulation of protein localization to plasma membrane; positive regulation of protein transport; positive regulation of Schwann cell migration; positive regulation of vascular associated smooth muscle cell migration; protein kinase C-activating G protein-coupled receptor signaling pathway; receptor-mediated endocytosis; regulation of actin cytoskeleton organization; regulation of cholesterol transport; regulation of phospholipase A2 activity
Reference #:  Q91ZX7 (UniProtKB)
Alt. Names/Synonyms: A2MR; AI316852; alpha 2-macroglobulin receptor; Alpha-2-macroglobulin receptor; CD91; lipoprotein receptor-related protein; low density lipoprotein receptor-related protein 1; Low-density lipoprotein receptor-related protein 1 515 kDa subunit; Low-density lipoprotein receptor-related protein 1 85 kDa subunit; Low-density lipoprotein receptor-related protein 1 intracellular domain; Lrp; LRP-1; LRP-515; LRP-85; Lrp1; LRPICD; Prolow-density lipoprotein receptor-related protein 1
Gene Symbols: Lrp1
Molecular weight: 504,742 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene