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PLCB1
an enzyme that catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. Binds to calmodulin. Uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. Activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variant isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase |
| Chromosomal Location of Human Ortholog: 3q36 |
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Cellular Component:
cytoplasm; cytosol; GABA-ergic synapse; glutamatergic synapse; membrane; nuclear chromatin; nuclear membrane; nuclear speck; nucleus; postsynapse; protein-containing complex
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Molecular Function:
calcium ion binding; calmodulin binding; enzyme binding; GTPase activator activity; lamin binding; phosphatidylinositol phospholipase C activity; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein homodimerization activity
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Biological Process:
activation of meiosis involved in egg activation; brain development; cellular response to fluoride; cellular response to glyceraldehyde; cellular response to ionomycin; cellular response to vasopressin; cerebral cortex development; fat cell differentiation; G protein-coupled acetylcholine receptor signaling pathway; G2/M transition of mitotic cell cycle; glutamate receptor signaling pathway; inositol trisphosphate biosynthetic process; inositol trisphosphate metabolic process; insulin-like growth factor receptor signaling pathway; interleukin-1-mediated signaling pathway; interleukin-12-mediated signaling pathway; interleukin-15-mediated signaling pathway; intracellular signal transduction; learning; lipid catabolic process; memory; negative regulation of monocyte extravasation; negative regulation of transcription, DNA-templated; phosphatidylinositol catabolic process; phosphatidylinositol metabolic process; phosphatidylinositol-mediated signaling; positive regulation of acrosome reaction; positive regulation of CD24 biosynthetic process; positive regulation of developmental growth; positive regulation of embryonic development; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of GTPase activity; positive regulation of interleukin-12 production; positive regulation of JNK cascade; positive regulation of myoblast differentiation; positive regulation of transcription, DNA-templated; postsynaptic modulation of chemical synaptic transmission; regulation of cell cycle; regulation of fertilization; regulation of G protein-coupled receptor signaling pathway; regulation of retrograde trans-synaptic signaling by endocanabinoid; release of sequestered calcium ion into cytosol; response to monosaccharide; response to organonitrogen compound; response to peptide hormone
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Reference #:
P10687
(UniProtKB)
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Alt. Names/Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1; Phosphb; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-beta-1; phospholipase C, beta 1 (phosphoinositide-specific); Phospholipase C-beta-1; Phospholipase C-beta1; Phospholipase C-I; PLC'1; PLC-154; PLC-beta-1; PLC-I; Plcb1; PLCbeta1; RATPHOSPHB
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Gene Symbols: Plcb1
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Molecular weight:
138,344 Da
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Basal Isoelectric point:
5.86
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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AMPK Signaling
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ErbB/HER Signaling
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GPCR Signaling to MAPKs
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