PLCB1 an enzyme that catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. Binds to calmodulin. Uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. Activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; Phospholipase
Chromosomal Location of Human Ortholog: 3q36
Cellular Component:  cytoplasm; cytosol; GABA-ergic synapse; glutamatergic synapse; membrane; nuclear chromatin; nuclear membrane; nuclear speck; nucleus; postsynapse; protein-containing complex
Molecular Function:  calcium ion binding; calmodulin binding; enzyme binding; GTPase activator activity; lamin binding; phosphatidylinositol phospholipase C activity; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein homodimerization activity
Biological Process:  activation of meiosis involved in egg activation; brain development; cellular response to fluoride; cellular response to glyceraldehyde; cellular response to ionomycin; cellular response to vasopressin; cerebral cortex development; fat cell differentiation; G protein-coupled acetylcholine receptor signaling pathway; G2/M transition of mitotic cell cycle; glutamate receptor signaling pathway; inositol trisphosphate biosynthetic process; inositol trisphosphate metabolic process; insulin-like growth factor receptor signaling pathway; interleukin-1-mediated signaling pathway; interleukin-12-mediated signaling pathway; interleukin-15-mediated signaling pathway; intracellular signal transduction; learning; lipid catabolic process; memory; negative regulation of monocyte extravasation; negative regulation of transcription, DNA-templated; phosphatidylinositol catabolic process; phosphatidylinositol metabolic process; phosphatidylinositol-mediated signaling; positive regulation of acrosome reaction; positive regulation of CD24 biosynthetic process; positive regulation of developmental growth; positive regulation of embryonic development; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of GTPase activity; positive regulation of interleukin-12 production; positive regulation of JNK cascade; positive regulation of myoblast differentiation; positive regulation of transcription, DNA-templated; postsynaptic modulation of chemical synaptic transmission; regulation of cell cycle; regulation of fertilization; regulation of G protein-coupled receptor signaling pathway; regulation of retrograde trans-synaptic signaling by endocanabinoid; release of sequestered calcium ion into cytosol; response to monosaccharide; response to organonitrogen compound; response to peptide hormone
Reference #:  P10687 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1; Phosphb; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-beta-1; phospholipase C, beta 1 (phosphoinositide-specific); Phospholipase C-beta-1; Phospholipase C-beta1; Phospholipase C-I; PLC'1; PLC-154; PLC-beta-1; PLC-I; Plcb1; PLCbeta1; RATPHOSPHB
Gene Symbols: Plcb1
Molecular weight: 138,344 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene