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5-LO
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. Belongs to the lipoxygenase family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.13.11.34; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Nuclear envelope; Oxidoreductase |
| Chromosomal Location of Human Ortholog: 6 E3|6 53.79 cM |
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Cellular Component:
cytoplasm; cytosol; dendrite; membrane; nuclear envelope; nuclear envelope lumen; nuclear matrix; nuclear membrane; nucleoplasm; nucleus; sarcolemma
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Molecular Function:
arachidonate 5-lipoxygenase activity; dioxygenase activity; iron ion binding; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; protein binding
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Biological Process:
acute inflammatory response; inflammatory response; leukotriene biosynthetic process; leukotriene metabolic process; leukotriene production involved in inflammatory response; oxidation-reduction process; positive regulation of cytochrome-c oxidase activity; positive regulation of vasoconstriction; sensory perception of pain
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Reference #:
P48999
(UniProtKB)
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Alt. Names/Synonyms: 5-L; 5-lipoxygenase; 5-LO; 5-LOX; 5LO; 5LX; AI850497; Alox5; Arachidonate 5-lipoxygenase; F730011J02; LOX5; Polyunsaturated fatty acid 5-lipoxygenase
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Gene Symbols: Alox5
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Molecular weight:
77,967 Da
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Basal Isoelectric point:
5.78
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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