5-LO Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. Belongs to the lipoxygenase family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.13.11.34; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Nuclear envelope; Oxidoreductase
Chromosomal Location of Human Ortholog: 6 E3|6 53.79 cM
Cellular Component:  cytoplasm; cytosol; dendrite; membrane; nuclear envelope; nuclear envelope lumen; nuclear matrix; nuclear membrane; nucleoplasm; nucleus; sarcolemma
Molecular Function:  arachidonate 5-lipoxygenase activity; dioxygenase activity; iron ion binding; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; protein binding
Biological Process:  acute inflammatory response; inflammatory response; leukotriene biosynthetic process; leukotriene metabolic process; leukotriene production involved in inflammatory response; oxidation-reduction process; positive regulation of cytochrome-c oxidase activity; positive regulation of vasoconstriction; sensory perception of pain
Reference #:  P48999 (UniProtKB)
Alt. Names/Synonyms: 5-L; 5-lipoxygenase; 5-LO; 5-LOX; 5LO; 5LX; AI850497; Alox5; Arachidonate 5-lipoxygenase; F730011J02; LOX5; Polyunsaturated fatty acid 5-lipoxygenase
Gene Symbols: Alox5
Molecular weight: 77,967 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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5-LO

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene