5-LO Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. Belongs to the lipoxygenase family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.13.11.34; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Nuclear envelope; Oxidoreductase
Chromosomal Location of human Ortholog: 10q11.21
Cellular Component:  cytosol; extracellular region; ficolin-1-rich granule lumen; nuclear envelope; nuclear envelope lumen; nuclear matrix; nuclear membrane; nucleoplasm; secretory granule lumen
Molecular Function:  arachidonate 5-lipoxygenase activity; iron ion binding; protein binding
Biological Process:  cytokine-mediated signaling pathway; interleukin-18-mediated signaling pathway; leukotriene biosynthetic process; leukotriene metabolic process; leukotriene production involved in inflammatory response; lipoxin biosynthetic process; lipoxygenase pathway; long-chain fatty acid biosynthetic process; neutrophil degranulation; oxidation-reduction process
Disease: Asthma, Susceptibility To
Reference #:  P09917 (UniProtKB)
Alt. Names/Synonyms: 5-lipoxygenase; 5-LO; 5-LOX; 5LPG; ALOX5; Arachidonate 5-lipoxygenase; arachidonic acid 5-lipoxygenase; leukotriene A4 synthase; LOG5; LOX-5; LOX5; MGC163204; Polyunsaturated fatty acid 5-lipoxygenase
Gene Symbols: ALOX5
Molecular weight: 77,983 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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5-LO

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene