5-LO arachidonate 5-lipoxygenase. Arachidonic acid promotes its phosphorylation by p38 MAPK-regulated MAPKAP kinases. Upregulated in glioblastoma multiforme and colon, pancreatic and bladder cancer. Note: This description may include information from UniProtKB.
Protein type: EC 1.13.11.34; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Nuclear envelope; Oxidoreductase
Chromosomal Location of Human Ortholog: 10q11.21
Cellular Component:  cytosol; extracellular region; ficolin-1-rich granule lumen; nuclear envelope; nuclear envelope lumen; nuclear matrix; nuclear membrane; nucleoplasm; secretory granule lumen
Molecular Function:  arachidonate 5-lipoxygenase activity; iron ion binding; protein binding
Biological Process:  cytokine-mediated signaling pathway; interleukin-18-mediated signaling pathway; leukotriene biosynthetic process; leukotriene metabolic process; leukotriene production involved in inflammatory response; lipoxin biosynthetic process; lipoxygenase pathway; long-chain fatty acid biosynthetic process; neutrophil degranulation; oxidation-reduction process
Disease: Asthma, Susceptibility To
Reference #:  P09917 (UniProtKB)
Alt. Names/Synonyms: 5-lipoxygenase; 5-LO; 5-LOX; 5LPG; ALOX5; Arachidonate 5-lipoxygenase; arachidonic acid 5-lipoxygenase; leukotriene A4 synthase; LOG5; LOX5; MGC163204
Gene Symbols: ALOX5
Molecular weight: 77,983 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

5-LO

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene