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5-LO
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. Belongs to the lipoxygenase family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.13.11.34; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Nuclear envelope; Oxidoreductase |
| Chromosomal Location of human Ortholog: 10q11.21 |
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Cellular Component:
cytosol; extracellular region; ficolin-1-rich granule lumen; nuclear envelope; nuclear envelope lumen; nuclear matrix; nuclear membrane; nucleoplasm; perinuclear region of cytoplasm; secretory granule lumen
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Molecular Function:
arachidonate 12(S)-lipoxygenase activity; arachidonate 5-lipoxygenase activity; arachidonate 8(S)-lipoxygenase activity; hydrolase activity; iron ion binding; protein binding
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Biological Process:
arachidonic acid metabolic process; dendritic cell migration; glucose homeostasis; hepoxilin biosynthetic process; humoral immune response; leukocyte chemotaxis involved in inflammatory response; leukocyte migration involved in inflammatory response; leukotriene A4 biosynthetic process; leukotriene biosynthetic process; leukotriene metabolic process; leukotriene production involved in inflammatory response; linoleic acid metabolic process; lipid oxidation; lipoxin biosynthetic process; lipoxygenase pathway; long-chain fatty acid biosynthetic process; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; negative regulation of inflammatory response; negative regulation of response to endoplasmic reticulum stress; negative regulation of sprouting angiogenesis; negative regulation of vascular wound healing; negative regulation of wound healing; positive regulation of bone mineralization; positive regulation of leukocyte adhesion to arterial endothelial cell; regulation of cellular response to oxidative stress; regulation of cytokine production involved in inflammatory response; regulation of fat cell differentiation; regulation of inflammatory response; regulation of inflammatory response to wounding; regulation of insulin secretion; regulation of reactive oxygen species biosynthetic process
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Disease: Asthma, Susceptibility To
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Reference #:
P09917
(UniProtKB)
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Alt. Names/Synonyms: 5-lipoxygenase; 5-LO; 5-LOX; 5LPG; ALOX5; Arachidonate 5-lipoxygenase; arachidonic acid 5-lipoxygenase; leukotriene A4 synthase; LOG5; LOX-5; LOX5; MGC163204; Polyunsaturated fatty acid 5-lipoxygenase
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Gene Symbols: ALOX5
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Molecular weight:
77,983 Da
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Basal Isoelectric point:
5.51
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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