|
5-LO
arachidonate 5-lipoxygenase. Arachidonic acid promotes its phosphorylation by p38 MAPK-regulated MAPKAP kinases. Upregulated in glioblastoma multiforme and colon, pancreatic and bladder cancer. Note: This description may include information from UniProtKB.
|
| Protein type: EC 1.13.11.34; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Nuclear envelope; Oxidoreductase |
| Chromosomal Location of Human Ortholog: 10q11.21 |
|
Cellular Component:
cytosol; extracellular region; ficolin-1-rich granule lumen; nuclear envelope; nuclear envelope lumen; nuclear matrix; nuclear membrane; nucleoplasm; secretory granule lumen
|
|
Molecular Function:
arachidonate 5-lipoxygenase activity; iron ion binding; protein binding
|
|
Biological Process:
cytokine-mediated signaling pathway; interleukin-18-mediated signaling pathway; leukotriene biosynthetic process; leukotriene metabolic process; leukotriene production involved in inflammatory response; lipoxin biosynthetic process; lipoxygenase pathway; long-chain fatty acid biosynthetic process; neutrophil degranulation; oxidation-reduction process
|
|
Disease: Asthma, Susceptibility To
|
|
Reference #:
P09917
(UniProtKB)
|
|
Alt. Names/Synonyms: 5-lipoxygenase; 5-LO; 5-LOX; 5LPG; ALOX5; Arachidonate 5-lipoxygenase; arachidonic acid 5-lipoxygenase; leukotriene A4 synthase; LOG5; LOX5; MGC163204
|
|
Gene Symbols: ALOX5
|
|
Molecular weight:
77,983 Da
|
|
Basal Isoelectric point:
5.51
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
|
