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PTP1B
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Phosphatase; Protein phosphatase, tyrosine (non-receptor) |
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Cellular Component:
cytoplasm; early endosome; endoplasmic reticulum; endoplasmic reticulum membrane; plasma membrane
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Molecular Function:
non-membrane spanning protein tyrosine phosphatase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity
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Biological Process:
actin cytoskeleton organization; endoplasmic reticulum unfolded protein response; negative regulation of ERK1 and ERK2 cascade; negative regulation of PERK-mediated unfolded protein response; peptidyl-tyrosine dephosphorylation; regulation of endocytosis; regulation of signal transduction
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Reference #:
O13016
(UniProtKB)
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Alt. Names/Synonyms: CPTP1; Protein-protein-tyrosine phosphatase HA2; Protein-tyrosine phosphatase 1B; Protein-tyrosine phosphatase, non-receptor type 1; PTN1; PTP-1B; PTP-HA2; PTP1B; PTPN1; Tyrosine-protein phosphatase non-receptor type 1
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Gene Symbols: PTPN1
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Molecular weight:
50,334 Da
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Basal Isoelectric point:
5.72
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Insulin Receptor Signaling
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