PTP1B a non-receptor phospho-tyrosine protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation and inactivation of PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. Negatively regulates insulin signaling by dephosphorylating the phosphotyrosine residues of insulin receptor. Also reported to dephosphorylate integrin, epidermal growth factor receptor, JAK2 and TYK2, regulating cell growth control and the cellular response to interferon. May regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. PTP1B knockout mice show resistance to dietary weight gain and enhanced insulin sensitivity, suggesting a possible role in treatment of obesity as well as type 2 diabetes. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Phosphatase; Protein phosphatase, tyrosine (non-receptor)
Cellular Component:  early endosome; endoplasmic reticulum membrane
Molecular Function:  protein binding; protein tyrosine phosphatase activity
Biological Process:  actin cytoskeleton reorganization; endoplasmic reticulum unfolded protein response; peptidyl-tyrosine dephosphorylation; regulation of endocytosis; regulation of signal transduction
Reference #:  O13016 (UniProtKB)
Alt. Names/Synonyms: CPTP1; Protein-protein-tyrosine phosphatase HA2; Protein-tyrosine phosphatase 1B; Protein-tyrosine phosphatase, non-receptor type 1; PTN1; PTP-1B; PTP-HA2; PTPN1; Tyrosine-protein phosphatase non-receptor type 1
Gene Symbols: PTPN1
Molecular weight: 50,334 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Insulin Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene