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LRP1
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Acts as an alpha-2-macroglobulin receptor. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. Belongs to the LDLR family. Most abundant in liver, brain and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. |
| Chromosomal Location of human Ortholog: 12q13.3 |
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Cellular Component:
basolateral plasma membrane; clathrin-coated pit; cytoskeleton; early endosome; endocytic vesicle membrane; Golgi apparatus; membrane; nucleus; plasma membrane; plasma membrane protein complex; receptor complex
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Molecular Function:
alpha-2 macroglobulin receptor activity; amyloid-beta binding; apolipoprotein binding; apolipoprotein receptor activity; calcium ion binding; cargo receptor activity; clathrin heavy chain binding; heparan sulfate proteoglycan binding; lipoprotein particle receptor binding; low-density lipoprotein particle receptor activity; protein binding; protein-containing complex binding; scavenger receptor activity; signaling receptor activity
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Biological Process:
amyloid-beta clearance; amyloid-beta clearance by cellular catabolic process; amyloid-beta clearance by transcytosis; aorta morphogenesis; apoptotic cell clearance; astrocyte activation involved in immune response; cellular response to amyloid-beta; enzyme-linked receptor protein signaling pathway; lipid metabolic process; lipoprotein transport; lysosomal transport; negative regulation of gene expression; negative regulation of metallopeptidase activity; negative regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of platelet-derived growth factor receptor-beta signaling pathway; negative regulation of SMAD protein signal transduction; negative regulation of smooth muscle cell migration; negative regulation of Wnt signaling pathway; phagocytosis; positive regulation of amyloid-beta clearance; positive regulation of cholesterol efflux; positive regulation of endocytosis; positive regulation of lipid transport; positive regulation of lysosomal protein catabolic process; positive regulation of protein binding; positive regulation of protein localization to plasma membrane; positive regulation of transcytosis; receptor internalization; receptor-mediated endocytosis; regulation of actin cytoskeleton organization; regulation of cholesterol transport; regulation of extracellular matrix disassembly; regulation of phospholipase A2 activity; retinoid metabolic process; transcytosis; transport across blood-brain barrier
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Disease: Developmental Dysplasia Of The Hip 3; Keratosis Pilaris Atrophicans
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Reference #:
Q07954
(UniProtKB)
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Alt. Names/Synonyms: A2MR; Alpha-2-macroglobulin receptor; APOER; Apolipoprotein E receptor; APR; CD91; FLJ16451; IGFBP-3R; IGFBP3R; IGFBP3R1; KPA; LDL receptor related protein 1; low density lipoprotein receptor-related protein 1; Low-density lipoprotein receptor-related protein 1 515 kDa subunit; Low-density lipoprotein receptor-related protein 1 85 kDa subunit; Low-density lipoprotein receptor-related protein 1 intracellular domain; LRP; LRP-1; LRP-515; LRP-85; LRP1; LRP1A; LRPICD; MGC88725; Prolow-density lipoprotein receptor-related protein 1; TbetaR-V/LRP-1/IGFBP-3 receptor; TGFBR5; type V tgf-beta receptor
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Gene Symbols: LRP1
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Molecular weight:
504,606 Da
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Basal Isoelectric point:
5.16
Predict pI for various phosphorylation states
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CST Pathways:
ESC Pluripotency and Differentiation
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Microtubule Dynamics
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mTOR Signaling
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Translation: eIF4E and p70S6K
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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