LRP1 Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Acts as an alpha-2-macroglobulin receptor. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. Belongs to the LDLR family. Most abundant in liver, brain and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component:  apical part of cell; axonal growth cone; basolateral plasma membrane; clathrin-coated pit; clathrin-coated vesicle; dendrite; early endosome; endocytic vesicle membrane; insulin-responsive compartment; integral component of plasma membrane; membrane; neuronal cell body; nucleus; plasma membrane; plasma membrane protein complex; receptor complex
Molecular Function:  alpha-2 macroglobulin receptor activity; amyloid-beta binding; apolipoprotein binding; apolipoprotein receptor activity; calcium ion binding; cargo receptor activity; clathrin heavy chain binding; coreceptor activity; heparan sulfate proteoglycan binding; lipoprotein particle receptor binding; low-density lipoprotein particle receptor activity; protease binding; protein binding; protein-containing complex binding; scavenger receptor activity; signaling receptor activity
Biological Process:  aging; amyloid-beta clearance; amyloid-beta clearance by cellular catabolic process; amyloid-beta clearance by transcytosis; aorta morphogenesis; apoptotic cell clearance; astrocyte activation involved in immune response; cell proliferation; cellular lipid catabolic process; cellular response to amyloid-beta; cerebral cortex development; chemoattraction of axon; lipid metabolic process; lipoprotein metabolic process; lipoprotein transport; lysosomal transport; negative regulation of cytosolic calcium ion concentration; negative regulation of focal adhesion assembly; negative regulation of neuron apoptotic process; negative regulation of neuron projection development; negative regulation of platelet-derived growth factor receptor-beta signaling pathway; negative regulation of smooth muscle cell migration; negative regulation of Wnt signaling pathway; phagocytosis; positive regulation of amyloid-beta clearance; positive regulation of axon extension involved in regeneration; positive regulation of cell death; positive regulation of chemokine (C-C motif) ligand 2 secretion; positive regulation of cholesterol efflux; positive regulation of cholesterol import; positive regulation of collateral sprouting of injured axon; positive regulation of cytosolic calcium ion concentration; positive regulation of endocytosis; positive regulation of ERK1 and ERK2 cascade; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of lipid transport; positive regulation of lysosomal protein catabolic process; positive regulation of phagocytosis; positive regulation of protein binding; positive regulation of protein localization to plasma membrane; positive regulation of Schwann cell migration; positive regulation of vascular associated smooth muscle cell migration; protein kinase C-activating G protein-coupled receptor signaling pathway; receptor internalization; receptor-mediated endocytosis; regulation of actin cytoskeleton organization; regulation of cholesterol transport; regulation of extracellular matrix disassembly; regulation of phospholipase A2 activity; retinoid metabolic process; transcytosis
Disease: Keratosis Pilaris Atrophicans
Reference #:  Q07954 (UniProtKB)
Alt. Names/Synonyms: A2MR; Alpha-2-macroglobulin receptor; APOER; Apolipoprotein E receptor; APR; CD91; FLJ16451; IGFBP3R; low density lipoprotein receptor-related protein 1; Low-density lipoprotein receptor-related protein 1 515 kDa subunit; Low-density lipoprotein receptor-related protein 1 85 kDa subunit; Low-density lipoprotein receptor-related protein 1 intracellular domain; LRP; LRP-1; LRP-515; LRP-85; LRP1; LRPICD; MGC88725; Prolow-density lipoprotein receptor-related protein 1; TbetaR-V/LRP-1/IGFBP-3 receptor; TGFBR5; type V tgf-beta receptor
Gene Symbols: LRP1
Molecular weight: 504,606 Da
Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene