NFkB-p100 a subunit of NF-kappa-B transcription complex (NFkB), which plays a crucial role in biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFkB consists of homo- or heterodimeric complexes formed from the five NFkB proteins in mammals: RelA, RelB, c-REL, NFkB1, and NFkB2. They form a variety of homodimers and heterodimers, each binding at kappa-B sites in the DNA, regulating distinct sets of genes. Different dimer combinations act as transcriptional activators or repressors. In a non-canonical activation pathway, the Nik-activated IKKA homodimer phosphorylates NFKB2-p100 associated with RelB, inducing its proteolytic processing to NFKB2-p52 and the formation of RelB/p52 complexes. The heterodimeric RelB/p52 complex is a transcriptional activator while the p52/p52 homodimer is a transcriptional repressor. NFKB2-p52 regulates the transcription of genes involved in immune response and acute phase reactions. Isoform 3 is a subunit of the NFkB protein complex that binds the HIV enhancer. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK/BMAL1 heterodimer. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 10q24.32
Cellular Component:  Bcl3/NF-kappaB2 complex; cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription coactivator activity
Biological Process:  aging; extracellular matrix organization; follicular dendritic cell differentiation; germinal center formation; NIK/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription by RNA polymerase II; positive regulation of type I interferon production; regulation of transcription, DNA-templated; response to cytokine; response to lipopolysaccharide; rhythmic process; spleen development
Disease: Immunodeficiency, Common Variable, 10
Reference #:  Q00653 (UniProtKB)
Alt. Names/Synonyms: DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; LYT-10; LYT10; NFKB2; NFKB2/p52; Nuclear factor NF-kappa-B p100 subunit; Nuclear factor NF-kappa-B p52 subunit; nuclear factor of kappa light chain gene enhancer in B-cells 2; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); Oncogene Lyt-10; p52
Gene Symbols: NFKB2
Molecular weight: 96,749 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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NFkB-p100

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein