Notch 2 a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. Affects the implementation of differentiation, proliferation and apoptotic programs. Cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 2q34
Cellular Component:  cell surface; cilium; cytosol; extracellular region; integral component of plasma membrane; nucleoplasm; nucleus; plasma membrane; receptor complex
Molecular Function:  calcium ion binding; enzyme binding; NF-kappaB binding; signaling receptor activity
Biological Process:  animal organ morphogenesis; atrial septum morphogenesis; bone remodeling; cell cycle arrest; cell differentiation; cell fate determination; cholangiocyte proliferation; ciliary body morphogenesis; defense response to bacterium; determination of left/right symmetry; embryonic limb morphogenesis; glomerular capillary formation; glomerular visceral epithelial cell development; heart looping; hepatocyte proliferation; humoral immune response; in utero embryonic development; inflammatory response to antigenic stimulus; interleukin-4 secretion; intrahepatic bile duct development; left/right axis specification; liver development; liver morphogenesis; marginal zone B cell differentiation; morphogenesis of an epithelial sheet; multicellular organism growth; myeloid dendritic cell differentiation; negative regulation of gene expression; negative regulation of growth rate; negative regulation of transcription by RNA polymerase II; Notch signaling pathway; placenta blood vessel development; placenta development; positive regulation of apoptotic process; positive regulation of BMP signaling pathway; positive regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of keratinocyte proliferation; positive regulation of osteoclast differentiation; positive regulation of Ras protein signal transduction; proximal tubule development; pulmonary valve morphogenesis; regulation of actin cytoskeleton reorganization; regulation of osteoclast development; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; tissue regeneration; wound healing
Reference #:  Q9QW30 (UniProtKB)
Alt. Names/Synonyms: Neurogenic locus notch homolog protein 2; NOTC2; Notch 2; Notch 2 extracellular truncation; Notch 2 intracellular domain; notch gene homolog 2; Notch homolog 2 (Drosophila); Notch2
Gene Symbols: Notch2
Molecular weight: 265,370 Da
Basal Isoelectric point: 5.02  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Notch 2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene