Notch 2 Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells. Belongs to the NOTCH family. Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 3 F2.2|3 42.42 cM
Cellular Component:  cell surface; cilium; cytoplasm; integral component of membrane; integral component of plasma membrane; membrane; nucleoplasm; nucleus; plasma membrane; receptor complex
Molecular Function:  calcium ion binding; enzyme binding; NF-kappaB binding; protein binding; signaling receptor activity
Biological Process:  animal organ morphogenesis; atrial septum morphogenesis; bone remodeling; cell cycle arrest; cell differentiation; cell fate determination; cholangiocyte proliferation; ciliary body morphogenesis; defense response to bacterium; determination of left/right symmetry; embryonic limb morphogenesis; glomerular capillary formation; glomerular visceral epithelial cell development; heart looping; hepatocyte proliferation; humoral immune response; in utero embryonic development; inflammatory response to antigenic stimulus; interleukin-4 secretion; intrahepatic bile duct development; left/right axis specification; liver development; liver morphogenesis; marginal zone B cell differentiation; morphogenesis of an epithelial sheet; multicellular organism development; multicellular organism growth; myeloid dendritic cell differentiation; negative regulation of gene expression; negative regulation of growth rate; negative regulation of transcription by RNA polymerase II; Notch signaling pathway; placenta blood vessel development; placenta development; positive regulation of apoptotic process; positive regulation of BMP signaling pathway; positive regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of keratinocyte proliferation; positive regulation of osteoclast differentiation; positive regulation of Ras protein signal transduction; proximal tubule development; pulmonary valve morphogenesis; regulation of actin cytoskeleton reorganization; regulation of developmental process; regulation of osteoclast development; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; wound healing
Reference #:  O35516 (UniProtKB)
Alt. Names/Synonyms: AI853703; Motch B; N2; Neurogenic locus notch homolog protein 2; NOTC2; Notch 2; Notch 2 extracellular truncation; Notch 2 intracellular domain; Notch gene homolog 2 (Drosophila); Notch2
Gene Symbols: Notch2
Molecular weight: 265,633 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Notch 2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene