PDGFC Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. Belongs to the PDGF/VEGF growth factor family. Expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract. Highly expressed in retinal pigment epithelia. Expressed in medulloblastoma. In the kidney, constitutively expressed in parietal epithelial cells of Bowman's capsule, tubular epithelial cells and in arterial endothelial cells (at protein level). Highly expressed in the platelets, prostate, testis and uterus. Higher expression is observed in uterine leiomyomata. Weaker expression in the spleen, thymus, heart, pancreas, liver, ovary cells and small intestine, and negligible expression in the colon and peripheral blood leukocytes. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q32.1
Cellular Component:  cell surface; cytosol; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi membrane; nucleus; plasma membrane
Molecular Function:  growth factor activity; platelet-derived growth factor receptor binding; protein binding; protein homodimerization activity
Biological Process:  activation of transmembrane receptor protein tyrosine kinase activity; animal organ morphogenesis; bone development; cellular response to amino acid stimulus; central nervous system development; digestive tract development; embryonic organ development; platelet-derived growth factor receptor signaling pathway; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of cold-induced thermogenesis; positive regulation of fibroblast proliferation; regulation of peptidyl-tyrosine phosphorylation; regulation of signaling receptor activity
Reference #:  Q9NRA1 (UniProtKB)
Alt. Names/Synonyms: Fallotein; PDGF-C; PDGFC; PDGFC latent form; PDGFC receptor-binding form; platelet derived growth factor C; Platelet-derived growth factor C; Platelet-derived growth factor C, latent form; Platelet-derived growth factor C, receptor-binding form; SCDGF; secretory growth factor-like protein; Spinal cord-derived growth factor; VEGF-E
Gene Symbols: PDGFC
Molecular weight: 39,029 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene