Notch 2 Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells. Belongs to the NOTCH family. Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of human Ortholog: 1p12
Cellular Component:  cell surface; endoplasmic reticulum membrane; extracellular region; Golgi membrane; integral component of plasma membrane; nucleoplasm; nucleus; plasma membrane; receptor complex
Molecular Function:  calcium ion binding; protein binding; signaling receptor activity
Biological Process:  animal organ morphogenesis; apoptotic process; atrial septum morphogenesis; bone remodeling; cell cycle arrest; cell fate determination; hemopoiesis; marginal zone B cell differentiation; multicellular organism development; negative regulation of apoptotic process; negative regulation of gene expression; negative regulation of growth rate; nervous system development; Notch signaling involved in heart development; Notch signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of keratinocyte proliferation; positive regulation of Ras protein signal transduction; pulmonary valve morphogenesis; regulation of actin cytoskeleton reorganization; regulation of osteoclast development; regulation of transcription, DNA-templated; stem cell population maintenance; transcription initiation from RNA polymerase II promoter
Disease: Alagille Syndrome 2; Hajdu-cheney Syndrome
Reference #:  Q04721 (UniProtKB)
Alt. Names/Synonyms: AGS2; HJCYS; hN2; N2ECD; N2ICD; Neurogenic locus notch homolog protein 2; NOTC2; Notch 2; Notch 2 extracellular truncation; Notch 2 intracellular domain; Notch homolog 2; Notch homolog 2 (Drosophila); notch receptor 2; NOTCH2
Gene Symbols: NOTCH2
Molecular weight: 265,405 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Notch Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Notch 2

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein