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Notch 2
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells. Belongs to the NOTCH family. Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo. Note: This description may include information from UniProtKB.
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| Protein type: Kinase, protein; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. |
| Chromosomal Location of human Ortholog: 1p12 |
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Cellular Component:
cell surface; cilium; endoplasmic reticulum membrane; extracellular region; Golgi membrane; nucleoplasm; nucleus; plasma membrane; receptor complex
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Molecular Function:
calcium ion binding; enzyme binding; NF-kappaB binding; protein binding; signaling receptor activity
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Biological Process:
activation of protein kinase B activity; animal organ morphogenesis; apoptotic process; atrial septum morphogenesis; atrioventricular node development; axon guidance; BMP signaling pathway; bone remodeling; cell fate determination; cellular response to tumor cell; cholangiocyte proliferation; ciliary body morphogenesis; defense response to bacterium; embryonic limb morphogenesis; glomerular capillary formation; heart looping; hemopoiesis; hepatocyte proliferation; humoral immune response; in utero embryonic development; inflammatory response to antigenic stimulus; intracellular signal transduction; intrahepatic bile duct development; left/right axis specification; marginal zone B cell differentiation; morphogenesis of an epithelial sheet; multicellular organism growth; myeloid dendritic cell differentiation; negative regulation of apoptotic process; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; nervous system development; Notch signaling involved in heart development; Notch signaling pathway; placenta blood vessel development; podocyte development; positive regulation of apoptotic process; positive regulation of BMP signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of keratinocyte proliferation; positive regulation of osteoclast differentiation; positive regulation of Ras protein signal transduction; proximal tubule development; pulmonary valve morphogenesis; regulation of osteoclast development; wound healing
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Disease: Alagille Syndrome 2; Hajdu-cheney Syndrome
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Reference #:
Q04721
(UniProtKB)
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Alt. Names/Synonyms: AGS2; HJCYS; hN2; N2ECD; N2ICD; Neurogenic locus notch homolog protein 2; NOTC2; Notch 2; Notch 2 extracellular truncation; Notch 2 intracellular domain; Notch homolog 2; Notch homolog 2 (Drosophila); notch receptor 2; NOTCH2
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Gene Symbols: NOTCH2
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Molecular weight:
265,405 Da
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Basal Isoelectric point:
4.95
Predict pI for various phosphorylation states
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CST Pathways:
ESC Pluripotency and Differentiation
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Notch Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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