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ITGB4
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. Belongs to the integrin beta chain family. Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. |
| Chromosomal Location of rat Ortholog: 10q32.1 |
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Cellular Component:
basal plasma membrane; basement membrane; cell cortex; cell junction; cell leading edge; cell surface; extracellular space; focal adhesion; glutamatergic synapse; hemidesmosome; integrin complex; nuclear membrane; nucleolus; plasma membrane; postsynaptic membrane; receptor complex
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Molecular Function:
cell adhesion molecule binding; G protein-coupled receptor binding; insulin-like growth factor I binding; integrin binding; neuregulin binding
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Biological Process:
autophagy; cell adhesion; cell adhesion mediated by integrin; cell migration; cell motility; cell-matrix adhesion; filopodium assembly; hemidesmosome assembly; integrin-mediated signaling pathway; mesodermal cell differentiation; myelination in peripheral nervous system; nail development; peripheral nervous system myelin formation; response to wounding; skin morphogenesis; trophoblast cell migration
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Reference #:
Q64632
(UniProtKB)
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Alt. Names/Synonyms: GP150; Integrin beta-4; integrin, beta 4; ITB4; Itgb4
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Gene Symbols: Itgb4
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Molecular weight:
200,589 Da
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Basal Isoelectric point:
5.6
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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PI3K/Akt Signaling
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