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ITGB4
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. Belongs to the integrin beta chain family. Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. |
| Chromosomal Location of Human Ortholog: 17q25.1 |
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Cellular Component:
cell junction; cell leading edge; cell surface; hemidesmosome; plasma membrane; receptor complex
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Molecular Function:
G protein-coupled receptor binding; protein binding
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Biological Process:
amelogenesis; autophagy; cell adhesion; cell motility; cell-matrix adhesion; digestive tract development; extracellular matrix organization; hemidesmosome assembly; mesodermal cell differentiation; nail development; renal system development; response to wounding; skin development
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Disease: Epidermolysis Bullosa Junctionalis With Pyloric Atresia; Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa, Junctional, Non-herlitz Type
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Reference #:
P16144
(UniProtKB)
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Alt. Names/Synonyms: CD104; CD104 antigen; GP150; Integrin beta-4; integrin beta-4 subunit; integrin subunit beta 4; integrin, beta 4; ITB4; ITGB4
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Gene Symbols: ITGB4
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Molecular weight:
202,167 Da
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Basal Isoelectric point:
5.74
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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PI3K/Akt Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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