p300 a histone acetyltransferase and transcriptional co-activator that regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Related to CPB (CREB-binding protein), and like CPB can stimulate transcription through activation of CREB. Specifically inhibited by the adenovirus oncoprotein E1A. A co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Methylated at R580 and R604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates the apoptotic response. Also methylated at R2142 by CARM1, which impairs interaction with NCoA2. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of mouse Ortholog: 15|15 E1
Cellular Component:  chromatin; cytoplasm; cytosol; histone acetyltransferase complex; nucleoplasm; nucleus; protein-containing complex; protein-DNA complex; transcription regulator complex
Molecular Function:  acetyltransferase activity; acyltransferase activity; antigen binding; beta-catenin binding; bHLH transcription factor binding; chromatin binding; chromatin DNA binding; cis-regulatory region sequence-specific DNA binding; damaged DNA binding; DNA binding; DNA-binding transcription factor binding; histone acetyltransferase activity; histone butyryltransferase activity; histone crotonyltransferase activity; histone H2B acetyltransferase activity; histone H3 acetyltransferase activity; histone H3K122 acetyltransferase activity; histone H4 acetyltransferase activity; histone lactyltransferase activity; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor; metal ion binding; mitogen-activated protein kinase binding; NF-kappaB binding; nuclear androgen receptor binding; nuclear glucocorticoid receptor binding; nuclear receptor binding; p53 binding; peptide butyryltransferase activity; peptide-lysine-N-acetyltransferase activity; peroxisome proliferator activated receptor binding; pre-mRNA intronic binding; promoter-specific chromatin binding; protein antigen binding; protein binding; protein kinase binding; protein propionyltransferase activity; protein-containing complex binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; SMAD binding; STAT family protein binding; transcription coactivator activity; transcription coactivator binding; transcription coregulator activity; transcription coregulator binding; transferase activity; zinc ion binding
Biological Process:  animal organ morphogenesis; apoptotic process; B cell differentiation; behavioral defense response; cartilage development; cell cycle; cell differentiation; cellular response to UV; chromatin remodeling; circadian rhythm; face morphogenesis; fat cell differentiation; heart development; histone acetylation; histone H3 acetylation; internal peptidyl-lysine acetylation; internal protein amino acid acetylation; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; learning or memory; lung development; macrophage derived foam cell differentiation; megakaryocyte development; multicellular organism growth; N-terminal peptidyl-lysine acetylation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of gluconeogenesis; negative regulation of miRNA metabolic process; negative regulation of protein-containing complex assembly; negative regulation of transcription by RNA polymerase II; peptidyl-lysine acetylation; peptidyl-lysine butyrylation; peptidyl-lysine crotonylation; peptidyl-lysine propionylation; platelet formation; positive regulation by host of viral transcription; positive regulation of axon extension; positive regulation of cell growth; positive regulation of cell growth involved in cardiac muscle cell development; positive regulation of cell size; positive regulation of cellular response to hypoxia; positive regulation of collagen biosynthetic process; positive regulation of DNA binding; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of glycoprotein biosynthetic process; positive regulation of histone acetylation; positive regulation of hydrogen peroxide-mediated programmed cell death; positive regulation of muscle atrophy; positive regulation of neuron projection development; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of protein acetylation; positive regulation of protein binding; positive regulation of protein import into nucleus; positive regulation of protein phosphorylation; positive regulation of protein secretion; positive regulation of proteolysis; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding; positive regulation of sarcomere organization; positive regulation of transcription by RNA polymerase II; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of translation; protein acetylation; protein destabilization; protein kinase B signaling; protein stabilization; protein-DNA complex assembly; regulation of androgen receptor signaling pathway; regulation of angiotensin metabolic process; regulation of DNA-templated transcription; regulation of glycolytic process; regulation of mitochondrion organization; regulation of transcription by RNA polymerase II; regulation of tubulin deacetylation; response to calcium ion; response to dexamethasone; response to estrogen; response to glucose; response to hypoxia; response to xenobiotic stimulus; rhythmic process; skeletal muscle tissue development; somitogenesis; swimming; thigmotaxis; transcription by RNA polymerase II; transcription initiation-coupled chromatin remodeling
Reference #:  B2RWS6 (UniProtKB)
Alt. Names/Synonyms: A430090G16; A730011L11; E1A binding protein p300; E1A-associated protein p300; Ep300; Histone acetyltransferase p300; Histone butyryltransferase p300; Histone crotonyltransferase p300; KAT3; KAT3B; p30; p300; p300 HAT; Protein 2-hydroxyisobutyryltransferase p300; Protein propionyltransferase p300
Gene Symbols: Ep300
Molecular weight: 263,305 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  G2/M DNA Damage Checkpoint  |  NF-kB Signaling  |  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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p300

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein