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APC
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. Belongs to the adenomatous polyposis coli (APC) family. Expressed in a variety of tissues: brain, small intestine, colon, thymus, skeletal muscle, heart, prostate, lung, spleen, ovary, testis kidney, placenta, blood and liver (PubMed:21643010, PubMed:27217144). Isoform 1A: Very strongly expressed in brain but has relatively low expression levels in other tissues (PubMed:19527921, PubMed:21643010, PubMed:27217144). Isoform 1B: Predominant form in all tissues except for brain, including gastric mucosa and blood (PubMed:19527921, PubMed:21643010, PubMed:27217144). 3 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Tumor suppressor |
| Chromosomal Location of rat Ortholog: 18p12 |
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Cellular Component:
adherens junction; axon; axonal growth cone; beta-catenin destruction complex; bicellular tight junction; catenin complex; cell body fiber; cell cortex; cell projection; cell projection membrane; centrosome; cytoplasm; cytoplasmic microtubule; dendrite; Golgi apparatus; growth cone; kinetochore; lamellipodium; lateral plasma membrane; microtubule; microtubule cytoskeleton; neuron projection; neuron projection terminus; neuronal cell body; nuclear membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; protein-containing complex; ruffle membrane; Scrib-APC-beta-catenin complex; synapse; synaptic vesicle membrane
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Molecular Function:
beta-catenin binding; cadherin binding; dynein complex binding; gamma-catenin binding; identical protein binding; microtubule binding; microtubule plus-end binding; protease binding; protein binding; protein kinase binding; protein kinase regulator activity; protein-containing complex binding; ubiquitin protein ligase binding
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Biological Process:
acinar cell proliferation; anterior/posterior pattern specification; apoptotic process; axis specification; axonogenesis; canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; canonical Wnt signaling pathway involved in positive regulation of apoptotic process; cell adhesion; cell division; cell fate specification; cell migration; cell population proliferation; cellular response to DNA damage stimulus; cellular response to nerve growth factor stimulus; chromosome organization; cytoplasmic microtubule organization; dorsal/ventral pattern formation; endothelial cell proliferation; epithelial cell apoptotic process; epithelial cell proliferation; epithelial cell proliferation involved in prostate gland development; establishment or maintenance of cell polarity; fibroblast apoptotic process; fibroblast migration; hair follicle development; insulin receptor signaling pathway; kidney development; MAPK cascade; metaphase/anaphase transition of mitotic cell cycle; microtubule depolymerization; microtubule polymerization; mitotic cytokinesis; mitotic spindle assembly checkpoint signaling; muscle cell cellular homeostasis; negative regulation of acinar cell proliferation; negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; negative regulation of cardiac muscle cell proliferation; negative regulation of cell cycle G1/S phase transition; negative regulation of cell population proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of endothelial cell proliferation; negative regulation of epithelial cell apoptotic process; negative regulation of epithelial cell proliferation; negative regulation of epithelial cell proliferation involved in prostate gland development; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of MAPK cascade; negative regulation of microtubule depolymerization; negative regulation of odontogenesis; negative regulation of Wnt signaling pathway; nervous system development; neuron projection development; odontogenesis; pancreas development; pattern specification process; positive regulation of apoptotic process; positive regulation of cell adhesion; positive regulation of cell death; positive regulation of cell differentiation; positive regulation of cell division; positive regulation of cell migration; positive regulation of cold-induced thermogenesis; positive regulation of fibroblast apoptotic process; positive regulation of fibroblast migration; positive regulation of microtubule polymerization; positive regulation of protein catabolic process; positive regulation of protein localization to centrosome; positive regulation of pseudopodium assembly; protein catabolic process; protein-containing complex assembly; proximal/distal pattern formation; regulation of attachment of spindle microtubules to kinetochore; regulation of cell cycle; regulation of cell differentiation; regulation of cell migration; regulation of epithelial cell differentiation; regulation of epithelial cell migration; regulation of glutamate metabolic process; regulation of microtubule-based process; regulation of nitrogen compound metabolic process; regulation of osteoblast differentiation; regulation of osteoclast differentiation; response to alcohol; response to xenobiotic stimulus; retina development in camera-type eye; skin development; somatic stem cell population maintenance; stem cell population maintenance; T cell differentiation in thymus; thymus development; Wnt signaling pathway
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Reference #:
P70478
(UniProtKB)
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Alt. Names/Synonyms: adenomatosis polyposis coli; adenomatous polyposis coli; Adenomatous polyposis coli protein; Apc; Protein APC; RATAPC
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Gene Symbols: Apc
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Molecular weight:
310,533 Da
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Basal Isoelectric point:
7.05
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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ESC Pluripotency and Differentiation
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Microtubule Dynamics
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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