APC a tumor suppressor. Defects in APC are a cause of familial adenomatous polyposis (FAP). Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. Activity is correlated with its phosphorylation state. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of Human Ortholog: 18 B1|18 18.53 cM
Cellular Component:  axon; axonal growth cone; beta-catenin destruction complex; bicellular tight junction; catenin complex; cell cortex; cell junction; cell projection; cell projection membrane; cell soma; cell-cell adherens junction; centrosome; cytoplasm; cytoplasmic microtubule; cytoskeleton; dendrite; growth cone; kinetochore; lamellipodium; lateral plasma membrane; membrane; microtubule; neuron projection; neuron projection terminus; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; Scrib-APC-beta-catenin complex; synapse
Molecular Function:  beta-catenin binding; gamma-catenin binding; identical protein binding; microtubule binding; microtubule plus-end binding; protease binding; protein binding; protein kinase binding; protein kinase regulator activity; ubiquitin protein ligase binding
Biological Process:  anterior/posterior pattern specification; axis specification; axonogenesis; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; canonical Wnt signaling pathway involved in positive regulation of apoptotic process; cell cycle arrest; cell fate specification; cell migration; cell proliferation; cellular response to DNA damage stimulus; chromosome organization and biogenesis; cytoplasmic microtubule organization; dorsal/ventral pattern formation; establishment and/or maintenance of cell polarity; hair follicle development; insulin receptor signaling pathway; kidney development; macromolecular complex assembly; metaphase/anaphase transition of mitotic cell cycle; mitotic cell cycle spindle assembly checkpoint; mitotic cytokinesis; muscle maintenance; negative regulation of apoptosis; negative regulation of canonical Wnt signaling pathway; negative regulation of cardiac muscle cell proliferation; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of epithelial cell proliferation; negative regulation of MAPKKK cascade; negative regulation of microtubule depolymerization; negative regulation of odontogenesis; negative regulation of Wnt signaling pathway; neuron projection development; pattern specification process; positive regulation of apoptosis; positive regulation of cell adhesion; positive regulation of cell death; positive regulation of cell differentiation; positive regulation of cell division; positive regulation of cell migration; positive regulation of epithelial cell differentiation; positive regulation of microtubule polymerization; positive regulation of protein catabolic process; positive regulation of protein localization to centrosome; positive regulation of pseudopodium assembly; protein homooligomerization; proximal/distal pattern formation; regulation of attachment of spindle microtubules to kinetochore; regulation of cell cycle; regulation of cell differentiation; regulation of cell migration; regulation of epithelial cell differentiation; regulation of glutamate metabolic process; regulation of microtubule-based process; regulation of nitrogen compound metabolic process; regulation of osteoblast differentiation; regulation of osteoclast differentiation; retina development in camera-type eye; skin development; somatic stem cell maintenance; stem cell maintenance; T cell differentiation in thymus; thymus development; Wnt receptor signaling pathway through beta-catenin; Wnt signaling pathway
Reference #:  Q61315 (UniProtKB)
Alt. Names/Synonyms: adenomatosis polyposis coli; Adenomatous polyposis coli protein; AI047805; Apc; AU020952; AW124434; CC1; mAPC; Min; multiple intestinal neoplasia; Protein APC
Gene Symbols: Apc
Molecular weight: 311,089 Da
Basal Isoelectric point: 7.44  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ESC Pluripotency and Differentiation  |  Microtubule Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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APC

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene