APC Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. Belongs to the adenomatous polyposis coli (APC) family. Expressed in a variety of tissues: brain, small intestine, colon, thymus, skeletal muscle, heart, prostate, lung, spleen, ovary, testis kidney, placenta, blood and liver (PubMed:21643010, PubMed:27217144). Isoform 1A: Very strongly expressed in brain but has relatively low expression levels in other tissues (PubMed:19527921, PubMed:21643010, PubMed:27217144). Isoform 1B: Predominant form in all tissues except for brain, including gastric mucosa and blood (PubMed:19527921, PubMed:21643010, PubMed:27217144). 3 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of human Ortholog: 5q22.2
Cellular Component:  adherens junction; beta-catenin destruction complex; bicellular tight junction; catenin complex; centrosome; cytoplasm; cytoplasmic microtubule; cytosol; Golgi apparatus; kinetochore; lamellipodium; lateral plasma membrane; microtubule; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; ruffle membrane; Wnt signalosome
Molecular Function:  beta-catenin binding; cadherin binding; dynein complex binding; gamma-catenin binding; microtubule binding; microtubule plus-end binding; protein binding; protein kinase binding; protein kinase regulator activity; ubiquitin protein ligase binding
Biological Process:  bicellular tight junction assembly; cell adhesion; cell fate specification; cell migration; DNA damage response; endocardial cushion morphogenesis; heart valve development; mitotic cytokinesis; mitotic spindle assembly checkpoint signaling; negative regulation of canonical Wnt signaling pathway; negative regulation of cell cycle G1/S phase transition; negative regulation of cell population proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of microtubule depolymerization; nervous system development; pattern specification process; positive regulation of apoptotic process; positive regulation of cell migration; positive regulation of cold-induced thermogenesis; positive regulation of protein catabolic process; positive regulation of protein localization to centrosome; positive regulation of pseudopodium assembly; proteasome-mediated ubiquitin-dependent protein catabolic process; protein-containing complex assembly; regulation of attachment of spindle microtubules to kinetochore; regulation of cell differentiation; regulation of microtubule-based process; Wnt signaling pathway
Disease: Colorectal Cancer; Desmoid Disease, Hereditary; Familial Adenomatous Polyposis 1; Gastric Adenocarcinoma And Proximal Polyposis Of The Stomach; Gastric Cancer; Hepatocellular Carcinoma
Reference #:  P25054 (UniProtKB)
Alt. Names/Synonyms: adenomatosis polyposis coli tumor suppressor; adenomatous polyposis coli; adenomatous polyposis coli (APC); Adenomatous polyposis coli protein; APC; APC regulator of WNT signaling pathway; APC, WNT signaling pathway regulator; BTPS2; Deleted in polyposis 2.5; DESMD; DP2; DP2.5; DP3; epididymis secretory sperm binding protein; GS; PPP1R46; Protein APC; protein phosphatase 1, regulatory subunit 46; truncated adenomatosis polyposis coli; WNT signaling pathway regulator
Gene Symbols: APC
Molecular weight: 311,646 Da
Basal Isoelectric point: 7.92  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ESC Pluripotency and Differentiation  |  Microtubule Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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