AMPKB2 Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). Belongs to the 5'-AMP-activated protein kinase beta subunit family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 1q21.1
Cellular Component:  cytosol; nucleoplasm; nucleotide-activated protein kinase complex
Molecular Function:  identical protein binding; protein binding
Biological Process:  carnitine shuttle; cell cycle arrest; fatty acid biosynthetic process; macroautophagy; positive regulation of cold-induced thermogenesis; protein phosphorylation; regulation of catalytic activity; regulation of fatty acid biosynthetic process; regulation of macroautophagy; regulation of signal transduction by p53 class mediator; signal transduction
Reference #:  O43741 (UniProtKB)
Alt. Names/Synonyms: 5'-AMP-activated protein kinase subunit beta-2; 5'-AMP-activated protein kinase, beta-2 subunit; AAKB2; AMPK beta 2; AMPK beta-2 chain; AMPK subunit beta-2; AMPKB2; MGC61468; PRKAB2; protein kinase, AMP-activated, beta 2 non-catalytic subunit
Gene Symbols: PRKAB2
Molecular weight: 30,302 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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AMPKB2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene