galectin-3 Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Extracellular matrix; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 14|14 C1
Cellular Component:  cell surface; cytoplasm; external side of plasma membrane; extracellular matrix; extracellular region; extracellular space; glial cell projection; immunological synapse; mitochondrial inner membrane; nucleus; spliceosomal complex
Molecular Function:  advanced glycation end-product receptor activity; carbohydrate binding; chemoattractant activity; disaccharide binding; Fc-gamma receptor I complex binding; IgE binding; laminin binding; monosaccharide binding; protein binding; protein phosphatase binding
Biological Process:  cell differentiation; eosinophil chemotaxis; extracellular matrix organization; immune system process; innate immune response; macrophage chemotaxis; monocyte chemotaxis; mononuclear cell migration; mRNA processing; negative regulation of apoptotic process; negative regulation of cell proliferation in bone marrow; negative regulation of endocytosis; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of immunological synapse formation; negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; negative regulation of T cell receptor signaling pathway; neutrophil chemotaxis; positive chemotaxis; positive regulation of angiogenesis; positive regulation of calcium ion import; positive regulation of cell proliferation; positive regulation of mononuclear cell migration; positive regulation of protein homodimerization activity; positive regulation of protein localization to plasma membrane; positive regulation of serotonin secretion; regulation of extrinsic apoptotic signaling pathway via death domain receptors; regulation of T cell apoptotic process; regulation of T cell proliferation; RNA splicing; skeletal system development
Reference #:  P16110 (UniProtKB)
Alt. Names/Synonyms: 35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Gal-3; gal3; Galactose-specific lectin 3; galect; Galectin-3; GBP; IgE-binding protein; L-3; L-34; L-34 galactoside-binding lectin; Laminin-binding protein; Lectin L-29; lectin, galactose binding, soluble 3; LEG3; Lgals3; Mac-; Mac-2; Mac-2 antigen
Gene Symbols: Lgals3
Molecular weight: 27,515 Da
Basal Isoelectric point: 8.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene