SF1
Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. Belongs to the BBP/SF1 family. Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: RNA splicing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor |
Chromosomal Location of mouse Ortholog: 19|19 A |
Cellular Component:
cytoplasm; nuclear body; nucleoplasm; nucleus; spliceosomal complex; U2AF complex
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Molecular Function:
identical protein binding; metal ion binding; mRNA binding; nucleic acid binding; RNA binding; zinc ion binding
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Biological Process:
Leydig cell differentiation; male sex determination; mRNA processing; mRNA splicing, via spliceosome; negative regulation of smooth muscle cell proliferation; nuclear body organization; regulation of mRNA splicing, via spliceosome; regulation of steroid biosynthetic process; RNA splicing
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Reference #:
Q64213
(UniProtKB)
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Alt. Names/Synonyms: BB094781; BBP; CW17; CW17R; Mammalian branch point-binding protein; mBBP; mZFM; SF01; Sf1; Splicing factor 1; Transcription factor ZFM1; WBP; WBP4; Zfm1; Zfp16; Zfp162; Zinc finger gene in MEN1 locus; Zinc finger protein 162
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Gene Symbols: Sf1
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Molecular weight:
70,403 Da
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Basal Isoelectric point:
9.14
Predict pI for various phosphorylation states
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