hnRNP I
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: RNA splicing; RNA-binding |
Chromosomal Location of human Ortholog: 19p13.3 |
Cellular Component:
nucleolus; nucleoplasm; nucleus
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Molecular Function:
DNA binding; mRNA binding; poly-pyrimidine tract binding; pre-mRNA binding; protein binding
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Biological Process:
IRES-dependent viral translational initiation; mRNA processing; negative regulation of mRNA splicing, via spliceosome; negative regulation of muscle cell differentiation; negative regulation of neuron differentiation; negative regulation of RNA splicing; neurogenesis; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of protein dephosphorylation; positive regulation of transcription by RNA polymerase II; regulation of alternative mRNA splicing, via spliceosome; regulation of cell differentiation; regulation of RNA splicing; RNA splicing
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Reference #:
P26599
(UniProtKB)
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Alt. Names/Synonyms: 57 kDa RNA-binding protein PPTB-1; Heterogeneous nuclear ribonucleoprotein I; heterogeneous nuclear ribonucleoprotein polypeptide I; hnRNP I; hnRNP I iso3; HNRNP-I; HNRNPI; HNRPI; polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I); polypyrimidine tract binding protein 1; Polypyrimidine tract-binding protein 1; pPTB; PTB; PTB-1; PTB-T; PTB2; PTB3; PTB4; PTBP1; RNA-binding protein
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Gene Symbols: PTBP1
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Molecular weight:
59,633 Da
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Basal Isoelectric point:
9.21
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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