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STX1B
Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. Belongs to the syntaxin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Vesicle |
| Chromosomal Location of mouse Ortholog: 7|7 F3 |
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Cellular Component:
axon; centrosome; cytoplasm; endomembrane system; membrane; neuromuscular junction; nuclear lamina; nucleoplasm; nucleus; plasma membrane; presynapse; presynaptic active zone membrane; presynaptic membrane; SNARE complex
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Molecular Function:
protein binding; protein domain specific binding; protein kinase binding; signaling receptor binding; SNAP receptor activity; SNARE binding
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Biological Process:
calcium ion-regulated exocytosis of neurotransmitter; exocytic insertion of neurotransmitter receptor to postsynaptic membrane; intracellular protein transport; negative regulation of synaptic vesicle recycling; neurotransmitter transport; positive regulation of excitatory postsynaptic potential; positive regulation of neurotransmitter secretion; positive regulation of spontaneous neurotransmitter secretion; protein localization to membrane; regulation of exocytosis; regulation of gene expression; regulation of synaptic vesicle priming; spontaneous neurotransmitter secretion; synaptic vesicle docking; synaptic vesicle exocytosis; synaptic vesicle fusion to presynaptic active zone membrane; vesicle docking; vesicle docking involved in exocytosis; vesicle fusion; vesicle-mediated transport
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Reference #:
P61264
(UniProtKB)
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Alt. Names/Synonyms: Stx1b; Stx1b1; Stx1b2; Stx1bl; Syn1b; syntaxin 1B; syntaxin 1B1; syntaxin 1B2; Syntaxin-1B
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Gene Symbols: Stx1b
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Molecular weight:
33,245 Da
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Basal Isoelectric point:
5.25
Predict pI for various phosphorylation states
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