CLTC iso2 a major protein component of the cytoplasmic face of coated vesicles and coated pits. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of Human Ortholog: 17q23.1
Cellular Component:  clathrin coat; clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; clathrin complex; clathrin-coated endocytic vesicle; clathrin-coated endocytic vesicle membrane; clathrin-coated vesicle; cytosol; endolysosome membrane; endosome; intracellular membrane-bounded organelle; lysosome; melanosome; mitotic spindle; mitotic spindle microtubule; plasma membrane; protein-containing complex; spindle; trans-Golgi network membrane
Molecular Function:  clathrin light chain binding; disordered domain specific binding; double-stranded RNA binding; low-density lipoprotein particle receptor binding; protein binding; protein kinase binding; structural molecule activity; ubiquitin-specific protease binding
Biological Process:  amyloid-beta clearance by transcytosis; antigen processing and presentation of exogenous peptide antigen via MHC class II; autophagy; cell division; clathrin coat assembly; clathrin-dependent endocytosis; intracellular protein transport; low-density lipoprotein particle clearance; low-density lipoprotein particle receptor catabolic process; membrane organization; mitotic cell cycle; negative regulation of hyaluronan biosynthetic process; negative regulation of protein localization to plasma membrane; receptor internalization; receptor-mediated endocytosis; regulation of mitotic spindle organization; retrograde transport, endosome to Golgi; transferrin transport; Wnt signaling pathway, planar cell polarity pathway
Reference #:  Q00610-2 (UniProtKB)
Alt. Names/Synonyms: Clathrin heavy chain 1; Clathrin heavy chain on chromosome 17; CLH-17; CLH1; CLH17; CLTC; CLTCL2; KIAA0034
Gene Symbols: CLTC
Molecular weight: 187,890 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  B Cell Receptor Signaling
Select Structure to View Below

CLTC iso2

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein