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H1C
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of human Ortholog: 6p22.2 |
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Cellular Component:
euchromatin; nucleosome; nucleus
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Molecular Function:
chromatin DNA binding; double-stranded DNA binding; nucleosomal DNA binding; protein binding; structural constituent of chromatin
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Biological Process:
chromosome condensation; histone H3-K27 trimethylation; histone H3-K4 trimethylation; negative regulation of DNA recombination; negative regulation of transcription by RNA polymerase II; nucleosome assembly
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Reference #:
P16403
(UniProtKB)
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Alt. Names/Synonyms: H1 histone family, member 2; H1-2; H1.2; H1.2 linker histone, cluster member; H12; H1C; H1F2; H1s-1; HIST1H1C; histone 1, H1c; histone cluster 1 H1 family member c; histone cluster 1, H1c; Histone H1.2; Histone H1c; Histone H1d; Histone H1s-1; MGC3992
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Gene Symbols: H1-2
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Molecular weight:
21,365 Da
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Basal Isoelectric point:
10.94
Predict pI for various phosphorylation states
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