H1C Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of rat Ortholog: 17p11
Cellular Component:  chromatin; heterochromatin; nucleolus; nucleosome; nucleus
Molecular Function:  ADP binding; AMP binding; ATP binding; calcium ion binding; chromatin DNA binding; dATP binding; DNA binding; double-stranded DNA binding; GTP binding; nucleotide binding; structural constituent of chromatin
Biological Process:  chromatin organization; chromosome condensation; histone H3-K27 trimethylation; histone H3-K4 trimethylation; negative regulation of transcription by RNA polymerase II; nucleosome assembly; regulation of transcription by RNA polymerase II
Reference #:  P15865 (UniProtKB)
Alt. Names/Synonyms: H1 histone family, member 4; H14; H1C; H1d; H1f2; H1f4; Hist1h1c; Hist1h1d; Histone 1d; histone cluster 1, H1d; Histone H1.2; Histone H1.4
Gene Symbols: H1f4
Molecular weight: 21,987 Da
Basal Isoelectric point: 11.1  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene