SYT1 Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes. Belongs to the synaptotagmin family. Expressed in melanocytes (PubMed:23999003). Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Membrane protein, integral; Vesicle
Chromosomal Location of Human Ortholog: 7q21
Cellular Component:  axon; cell junction; chromaffin granule membrane; cytoplasm; dense core granule; excitatory synapse; exocytic vesicle; glutamatergic synapse; Golgi apparatus; hippocampal mossy fiber to CA3 synapse; integral component of synaptic vesicle membrane; intracellular organelle; neuron projection; neuron projection terminus; plasma membrane; presynaptic membrane; secretory granule; synaptic vesicle; synaptic vesicle membrane
Molecular Function:  calcium ion binding; calcium ion sensor activity; calcium-dependent phospholipid binding; calcium-dependent protein binding; calmodulin binding; clathrin binding; identical protein binding; low-density lipoprotein particle receptor binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; phospholipid binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activity; SNARE binding; syntaxin binding; syntaxin-1 binding; syntaxin-3 binding
Biological Process:  brain development; calcium ion regulated exocytosis; calcium ion-regulated exocytosis of neurotransmitter; calcium-dependent activation of synaptic vesicle fusion; cellular response to calcium ion; detection of calcium ion; fast, calcium ion-dependent exocytosis of neurotransmitter; neurotransmitter secretion; positive regulation of calcium ion-dependent exocytosis; positive regulation of calcium ion-dependent exocytosis of neurotransmitter; positive regulation of dendrite extension; positive regulation of synaptic transmission; positive regulation of vesicle fusion; protein heterooligomerization; protein homooligomerization; regulation of calcium ion-dependent exocytosis; regulation of dopamine secretion; regulation of regulated secretory pathway; regulation of synaptic transmission, glutamatergic; regulation of synaptic vesicle exocytosis; response to calcium ion; spontaneous neurotransmitter secretion; synaptic vesicle endocytosis; synaptic vesicle exocytosis; synchronous neurotransmitter secretion; vesicle docking; vesicle-mediated transport
Reference #:  P21707 (UniProtKB)
Alt. Names/Synonyms: p65; synaptotagmin 1; Synaptotagmin I; Synaptotagmin-1; Syt1; SytI
Gene Symbols: Syt1
Molecular weight: 47,399 Da
Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene