PTP-SL Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily. Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine
Chromosomal Location of mouse Ortholog: 10|10 D2
Cellular Component:  cell junction; cytoplasm; cytosol; integral component of membrane; membrane; plasma membrane
Molecular Function:  hydrolase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity
Biological Process:  dephosphorylation; ERBB2 signaling pathway; negative regulation of epithelial cell migration; negative regulation of ERK1 and ERK2 cascade; protein dephosphorylation
Reference #:  Q62132 (UniProtKB)
Alt. Names/Synonyms: Gmcp1; mPTP213; OTTMUSP00000032010; Phosphotyrosine phosphatase 13; protein tyrosine phosphatase, receptor type, R; Protein-tyrosine-phosphatase SL; protein-tyrosine-phosphatase-SL; PTP; PTP-SL; Ptp13; PTPBR7; Ptprr; R-PTP-R; Receptor-type tyrosine-protein phosphatase R; RPTPRR; STEP-like PTPase
Gene Symbols: Ptprr
Molecular weight: 74,036 Da
Basal Isoelectric point: 7.9  Predict pI for various phosphorylation states
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PTP-SL

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene