AQP0 Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling. Belongs to the MIP/aquaporin (TC 1.A.8) family. Major component of lens fiber gap junctions. Note: This description may include information from UniProtKB.
Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family
Chromosomal Location of rat Ortholog: 7q11
Cellular Component:  apical plasma membrane; endoplasmic reticulum; gap junction; integral component of membrane; integral component of plasma membrane; intracellular canaliculus; intracellular membrane-bounded organelle; membrane; plasma membrane
Molecular Function:  calmodulin binding; structural constituent of eye lens; water channel activity
Biological Process:  canalicular bile acid transport; gap junction-mediated intercellular transport; lens development in camera-type eye; positive regulation of cell adhesion; protein homotetramerization; transmembrane transport; visual perception; water transport
Reference #:  P09011 (UniProtKB)
Alt. Names/Synonyms: Aqp0; Aquaporin-0; Lens fiber major intrinsic protein; major intrinsic protein of eye lens fiber; major intrinsic protein of lens fiber; Mip; MIP26; MP26
Gene Symbols: Mip
Molecular weight: 27,891 Da
Basal Isoelectric point: 9.47  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene