AQP0
Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling. Belongs to the MIP/aquaporin (TC 1.A.8) family. Major component of lens fiber gap junctions. Note: This description may include information from UniProtKB.
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Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family |
Chromosomal Location of human Ortholog: 12q13.3 |
Cellular Component:
apical plasma membrane; endoplasmic reticulum; gap junction; plasma membrane
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Molecular Function:
calmodulin binding; protein binding; structural constituent of eye lens; water channel activity
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Biological Process:
gap junction-mediated intercellular transport; lens development in camera-type eye; positive regulation of cell adhesion; protein homotetramerization; response to stimulus; transmembrane transport; visual perception; water transport
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Disease: Cataract 15, Multiple Types
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Reference #:
P30301
(UniProtKB)
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Alt. Names/Synonyms: AQP0; aquaporin 0; Aquaporin-0; CTRCT15; Lens fiber major intrinsic protein; LIM1; major intrinsic protein of lens fiber; MIP; MIP26; MP26
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Gene Symbols: MIP
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Molecular weight:
28,122 Da
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Basal Isoelectric point:
8.62
Predict pI for various phosphorylation states
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