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SNAPIN
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Belongs to the SNAPIN family. Expressed in male germ cells of adult testis (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: Vesicle |
| Chromosomal Location of rat Ortholog: 2q34 |
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Cellular Component:
acrosomal vesicle; axon cytoplasm; BLOC-1 complex; BORC complex; cytoplasmic vesicle; cytosol; Golgi membrane; lysosomal membrane; manchette; perinuclear region of cytoplasm; secretory granule; synapse; synaptic vesicle; synaptic vesicle membrane
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Molecular Function:
protein binding; SNARE binding
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Biological Process:
anterograde axonal transport; anterograde synaptic vesicle transport; autophagosome maturation; chemical synaptic transmission; endosome to lysosome transport; establishment of vesicle localization; intracellular protein transport; late endosome to lysosome transport; lysosomal lumen acidification; lysosome localization; lysosome organization; negative regulation of neuron projection development; neuron cellular homeostasis; neuron projection development; protein maturation; protein-containing complex localization; regulation of protein binding; regulation of synaptic vesicle exocytosis; retrograde axonal transport; synaptic vesicle exocytosis; synaptic vesicle fusion to presynaptic active zone membrane; synaptic vesicle maturation; synaptic vesicle transport; terminal button organization
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Reference #:
P60192
(UniProtKB)
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Alt. Names/Synonyms: MGC112927; SNAP-associated protein; Snapap; Snapin; SNARE associated protein snapin; SNARE-associated protein Snapin; synaptosomal-associated protein 25-binding protein
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Gene Symbols: Snapin
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Molecular weight:
14,904 Da
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Basal Isoelectric point:
9.35
Predict pI for various phosphorylation states
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