myelin P0 Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction. Belongs to the myelin P0 protein family. Found only in peripheral nervous system Schwann cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral
Chromosomal Location of rat Ortholog: 13q24
Cellular Component:  basolateral plasma membrane; integral component of plasma membrane; lysosome; myelin sheath; plasma membrane; rough endoplasmic reticulum
Biological Process:  cell aggregation; cell-cell adhesion via plasma-membrane adhesion molecules; cell-cell junction maintenance; myelination; negative regulation of apoptotic process
Reference #:  P06907 (UniProtKB)
Alt. Names/Synonyms: MPP; Mpz; myelin P0; Myelin peripheral protein; Myelin protein P0; Myelin protein zero; Myelin protein zero (Charcot-Marie-Tooth neuropathy 1B); MYP0; P0
Gene Symbols: Mpz
Molecular weight: 27,571 Da
Basal Isoelectric point: 9.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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myelin P0

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene