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myelin P0
Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction. Belongs to the myelin P0 protein family. Found only in peripheral nervous system Schwann cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Membrane protein, integral |
| Chromosomal Location of mouse Ortholog: 1 H3|1 79.05 cM |
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Cellular Component:
basolateral plasma membrane; membrane; plasma membrane
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Molecular Function:
protein binding
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Biological Process:
cell aggregation; cell-cell adhesion via plasma-membrane adhesion molecules; cell-cell junction maintenance; myelination; negative regulation of apoptotic process
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Reference #:
P27573
(UniProtKB)
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Alt. Names/Synonyms: MPP; Mpz; myelin P0; Myelin peripheral protein; Myelin protein P0; Myelin protein zero; MYP0; OTTMUSP00000023997; OTTMUSP00000023998; P-zero; P0
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Gene Symbols: Mpz
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Molecular weight:
27,622 Da
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Basal Isoelectric point:
9.5
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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