NME1
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. Belongs to the NDK family. Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.4.6; Kinase, nucleoside diphosphate; Kinase, other; NDK family; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other group; Protein kinase, histidine; Tumor suppressor
Cellular Component: centrosome; cytosol; intermediate filament; mitochondrial outer membrane; nucleus; perinuclear region of cytoplasm; ruffle membrane
Molecular Function: ATP binding; DNA nuclease activity; enzyme binding; gamma-tubulin binding; GTP binding; identical protein binding; intermediate filament binding; magnesium ion binding; nucleoside diphosphate kinase activity; protein binding; protein kinase binding; ribosomal small subunit binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; single-stranded DNA binding
Biological Process: cell differentiation; cellular response to fatty acid; cellular response to glucose stimulus; cellular response to xenobiotic stimulus; CTP biosynthetic process; DNA metabolic process; endocytosis; GTP biosynthetic process; hippocampus development; lactation; mammary gland development; negative regulation of gene expression; negative regulation of myeloid leukocyte differentiation; phosphorylation; positive regulation of DNA binding; positive regulation of epithelial cell proliferation; positive regulation of neuron projection development; response to amine; response to cAMP; response to testosterone; response to xenobiotic stimulus; UTP biosynthetic process
